CARODEL

Use of Microorganisms for Carotenoids Delivery: Next Generation of Probiotics for Cardiovascular Disease

Coordinatore	PRODIGEST    more  Organization address address: TECHNOLOGIEPARK 3 city: GENT ZWIJNAARDE postcode: 9052 contact info Titolo: Dr. Nome: Sam Cognome: Possemiers Email: send email Telefono: +32 92411190
Nazionalità Coordinatore	Belgium [BE]
Totale costo	2˙574˙757 €
EC contributo	1˙996˙823 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2013-7-single-stage
Funding Scheme	CP-TP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-12-01   -   2015-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	PRODIGEST  Organization address address: TECHNOLOGIEPARK 3 city: GENT ZWIJNAARDE postcode: 9052 contact info Titolo: Dr. Nome: Sam Cognome: Possemiers Email: send email Telefono: +32 92411190	BE (GENT ZWIJNAARDE)	coordinator	648˙771.20
2	SPOREGEN LIMITED  Organization address address: QUEENS ROAD 3 WESTLEY GATE city: READING BERKSHIRE postcode: RG1 4AP contact info Titolo: Prof. Nome: Simon Cognome: Cutting Email: send email Telefono: +44 1784443760	UK (READING BERKSHIRE)	participant	312˙868.80
3	BIOACTOR BV  Organization address address: OXFORDLAAN 70 city: MAASTRICHT postcode: 6229 EV contact info Titolo: Mr. Nome: Hans Cognome: Van Der Saag Email: send email Telefono: +31 437114555	NL (MAASTRICHT)	participant	304˙311.20
4	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Mrs. Nome: Sylvie Cognome: Modeste Email: send email Telefono: 33432722067 Fax: 33432722072	FR (PARIS CEDEX 07)	participant	191˙358.40
5	UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.  Organization address address: Corso Umberto I 40 city: NAPOLI postcode: 80138 contact info Titolo: Prof. Nome: Ezio Cognome: Ricca Email: send email Telefono: +39 081679036 Fax: +39 081679233	IT (NAPOLI)	participant	188˙938.00
6	BIOPOLIS SL  Organization address address: CALLE CATEDRATICO AGUSTIN ESCARDINO 9 city: PATERNA VALENCIA postcode: 46980 contact info Titolo: Ms. Nome: Iryna Cognome: Sukhotska Email: send email Telefono: +34 963160299	ES (PATERNA VALENCIA)	participant	154˙610.00
7	UNIVERSITEIT GENT  Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 contact info Titolo: Ms. Nome: Evelien Cognome: Vandevelde Email: send email Telefono: 3292643633 Fax: 3292643583	BE (GENT)	participant	112˙432.40
8	ORGANIC WASTE SYSTEMS NV  Organization address address: DOK NOORD 5 city: GENT postcode: 9000 contact info Titolo: Mr. Nome: Steven Cognome: De Meester Email: send email Telefono: +32 92330204	BE (GENT)	participant	83˙533.00

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 Obiettivo del progetto (Objective)

'CARODEL aims to valorise the results from the previous FP7 COLORSPORE project, in which initial isolation and characterization work was performed on Bacillus strains producing gastric-stable carotenoids. As the stability in the gastrointestinal tract (GIT), antioxidant activity and bioavailability of particular Bacillus carotenoids was shown to be higher than those of common dietary carotenoids, the conclusions from COLORSPORE provided strong and compelling reasons to support further development and commercialisation of these bacteria-derived carotenoids. CARODEL will therefore focus on the development of an efficient oral delivery strategy of such highly active carotenoids, in combination with evaluation of potential direct health-beneficial (probiotic) activity of the Bacillus delivery vehicle, with the ultimate aim to improve biomarkers associated with (the prevention of) cardiovascular disease (CVD). The relevance of using carotenoids for CVD prevention was recently shown by a positive EFSA opinion on the use of tomato lycopene for maintenance of a healthy blood flow. In practice, effective delivery of the carotenoids to the human body will be compared upon administration as i) vegetative Bacillus cells, ii) Bacillus spores or iii) extracted carotenoids. In parallel, the ability of the Bacillus strain to exert bona fide effects (i.e., effects on the host microbiota, metabolism and immunity) will be investigated using in vitro gut models and in vivo rat studies. Based on this, the best delivery strategy will be selected and validated in a human study, in which carotenoid bioavailability will be validated as well as endpoints related to CVD biomarkers and potential probiotic activity. In combination with a full safety assessment, a proof-of-concept production strategy and development of a business plan, the scientific evidence compiled in this project will provide a framework for efficient further commercialisation of a well-documented Bacillus carotenoid product'