INFACT
Functional materials for fast diagnosis of wound infection
| Coordinatore | UNIVERSITAET FUER BODENKULTUR WIEN
Organization address
address: Gregor Mendel Strasse 33 contact info |
| Nazionalità Coordinatore | Austria [AT] |
| Totale costo | 6˙151˙922 € |
| EC contributo | 4˙337˙973 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2013-SME-7 |
| Funding Scheme | CP-TP |
| Anno di inizio | 2014 |
| Periodo (anno-mese-giorno) | 2014-01-01 - 2017-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAET FUER BODENKULTUR WIEN
Organization address
address: Gregor Mendel Strasse 33 contact info |
AT (WIEN) | coordinator | 661˙811.00 |
| 2 |
CONVATEC LIMITED
Organization address
address: GDC FIRST AVENUE - DEESIDE INDUSTRIAL PARK contact info |
UK (DEESIDE FLINTSHIRE) | participant | 497˙380.00 |
| 3 |
SYNOVO GMBH
Organization address
address: Paul Ehrlich Str 15 contact info |
DE (TUEBINGEN) | participant | 489˙480.00 |
| 4 |
UNIVERSITAT POLITECNICA DE CATALUNYA
Organization address
address: Jordi Girona 31 contact info |
ES (BARCELONA) | participant | 464˙231.00 |
| 5 |
BAR ILAN UNIVERSITY
Organization address
address: BAR ILAN UNIVERSITY CAMPUS contact info |
IL (RAMAT GAN) | participant | 392˙320.00 |
| 6 |
DI DR ANDREAS PAAR KG
Organization address
address: GIRARDIGASSE 6/1 contact info |
AT (GRAZ) | participant | 381˙980.00 |
| 7 |
Associacao Universidade-Empresa para o Desenvolvimento - TecMinho
Organization address
address: Campus de Azurem da Universidade do Minho contact info |
PT (Guimaraes) | participant | 344˙760.00 |
| 8 |
S.C. DAVO STAR IMPEX SRL
Organization address
address: STR VALEA OTULUI 77-79 SECTOR 6 contact info |
RO (BUCHAREST) | participant | 307˙760.00 |
| 9 |
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Organization address
address: Schoemakerstraat 97 contact info |
NL (DEN HAAG) | participant | 306˙046.00 |
| 10 |
STICHTING MEDISCH SPECTRUM TWENTE
Organization address
address: HAAKSBERGERSTRAAT 55 contact info |
NL (ENSCHEDE) | participant | 293˙125.00 |
| 11 |
OSM-DAN LTD.
Organization address
address: Pekeris Street 4 contact info |
IL (REHOVOT) | participant | 199˙080.00 |
Mappa
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Obiettivo del progetto (Objective)
'Early detection of an incipient wound infection is a challenge for the attending physician , since its early diagnosis allows the timely initiation of treatment, thus reducing the severity of the disease . Currently, however, wound infection is not diagnosed until becoming already evident. As a consequence, the treatment of the patient is further complicated and more likely to have a negative outcome4. Often wounds are treated with antibiotics before even the infection appears, leading to overdoses and development of bacterial resistance to antibiotics. Considering that optimal efficiency is reached when a material serves multiple functions without compromise, consortium partners have discovered the means to convert wound dressings into a diagnostic tool capable to inform both patient and therapist about the wound status, thus directing towards the following therapeutic step. The proposed functional materials include a real time diagnostic reaction that positively influences the wound healing due to the timely intervention to treat infection or proteolytic stasis in the wound The novel InFact technology will be translated into a low-cost, real-time diagnostic tool as a constituent part of a wound dressing material, i.e. the 'triple-P' materials concept: - Protective - by a decoy substrate for destructive proteases - Predictive – providing a cumulative wound status signal to predict the infection transition - Proactive - changing the dressing according to a signal, rather than on a schedule base, will provide therapeutic response in time, and not too late. More specifically, the functional materials (e.g. absorbent fibres and hydrocolloid pads) will incorporate immobilized substrates for three enzymes: myeloperoxidase, lysozyme and elastase. Upon infection, these enzymatic activities are highly elevated in wound fluids, and can be detected by the color change of the functional materials, visible via a window in the dressing.'