DNA NANO-ROUTERS

Logical re-routing of cellular communication networks by DNA origami nanorobot

Coordinatore	BAR ILAN UNIVERSITY    more  Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 contact info Titolo: Ms. Nome: Estelle Cognome: Waise Email: send email Telefono: +972 3 5317439 Fax: +972 3 6353277
Nazionalità Coordinatore	Israel [IL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-12-01   -   2017-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	BAR ILAN UNIVERSITY  Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 contact info Titolo: Ms. Nome: Estelle Cognome: Waise Email: send email Telefono: +972 3 5317439 Fax: +972 3 6353277	IL (RAMAT GAN)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Almost every aspect of higher organism biology such as metabolism, growth and immunity, is regulated by intricate communication networks between multiple cell types. The ability to skew or interfere with these networks could lead to new ways to alleviate diseases caused or maintained by the interacting cells. However, since these cells are often dispersed across the entire organism, precise modulation of a single communication line is very challenging. In this project I propose to achieve this goal by DNA origami nanorobots programmed as routing devices for cell-cell communication. Each nanorobot is programmed to collect and sequester a specific type of signal molecule (cytokine, hormone etc.), and deliver it exclusively to a specific type of cell. Once programmed, a large group of nanorobots (~1016) effectively controls the traffic of signal molecules within an entire network, rendering it susceptible to arbitrary manipulations. These include re-routing signals to different cell addresses, up- or down-tuning the traffic volume in the path, or preventing a specific cell type from transmitting and receiving signals. This technology presents an advanced working draft towards automated biology as a strategy to solve challenges such as food, sustainable energy, emerging diseases etc.'