ACTION
Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strateg
| Coordinatore | STICHTING VU-VUMC
Organization address
address: DE BOELELAAN 1105 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 8˙742˙725 € |
| EC contributo | 5˙999˙079 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2014 |
| Periodo (anno-mese-giorno) | 2014-06-01 - 2019-05-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
STICHTING VU-VUMC
Organization address
address: DE BOELELAAN 1105 contact info |
NL (AMSTERDAM) | coordinator | 1˙607˙699.00 |
| 2 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 569˙440.00 |
| 3 |
KING'S COLLEGE LONDON
Organization address
address: Strand contact info |
UK (LONDON) | participant | 560˙982.80 |
| 4 |
HELSINGIN YLIOPISTO
Organization address
address: YLIOPISTONKATU 4 contact info |
FI (HELSINGIN YLIOPISTO) | participant | 507˙520.00 |
| 5 |
DIAGENODE
Organization address
address: RUE DU BOIS SAINT JEAN 3 LIEGE PARK SCIENCE contact info |
BE (SERAING) | participant | 499˙030.00 |
| 6 |
UNIVERSITA DEGLI STUDI DI CAGLIARI
Organization address
address: VIA UNIVERSITA 40 contact info |
IT (CAGLIARI) | participant | 475˙946.60 |
| 7 |
UNIVERSITEIT LEIDEN
Organization address
address: RAPENBURG 70 contact info |
NL (LEIDEN) | participant | 419˙452.00 |
| 8 |
Good Biomarker Sciences
Organization address
address: TEIJLINGERLAAN 59 contact info |
NL (SASSENHEIM) | participant | 418˙200.00 |
| 9 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | participant | 392˙100.00 |
| 10 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | participant | 278˙700.00 |
| 11 |
University of Notre Dame du Lac
Organization address
address: Main Building 511 contact info |
US (Notre Dame) | participant | 270˙009.00 |
| 12 |
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Organization address
address: "Herston Road, 300" contact info |
AU (HERSTON) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, and clinical fields, and combining such interdisciplinary expertise the ACTION consortium will dissect the etiology and pathogenesis of aggression. Based on new insights, ACTION will inform the development of novel diagnostic tools and causative targets and guide the development of treatment and prevention strategies. ACTION is built on interrelated work packages with a focus on a) clinical epidemiology and current classification and treatment problems; b) genetic epidemiology, including Genome Wide Association studies and epigenetics; c) gene-environment correlation and interaction; d) biomarkers and metabolomics. ACTION will deliver an overarching framework that combines a thorough understanding of pathways leading to aggression with a map of current gaps, best practices on clinical, ethical, legal, and social issues. Based on this framework, ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.'