DESIGN2HEAL

Rational design of scaffold architecture and functionalization to induce healing and tissue regeneration

Coordinatore	UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙994˙200 €
EC contributo	1˙994˙200 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-CoG
Funding Scheme	ERC-CG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-03-01   -   2019-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT  Organization address address: JOSEF-SCHNEIDER-STRASSE 2 city: WUERZBURG postcode: 97080 contact info Titolo: Dr. Nome: Andrea Cognome: Thelen-Frölich Email: send email Telefono: +49 93120147794 Fax: +49 93120147414	DE (WUERZBURG)	hostInstitution	1˙994˙200.00
2	UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT  Organization address address: JOSEF-SCHNEIDER-STRASSE 2 city: WUERZBURG postcode: 97080 contact info Titolo: Prof. Nome: Jürgen Cognome: Groll Email: send email Telefono: +49 93120173510 Fax: +49 93120173500	DE (WUERZBURG)	hostInstitution	1˙994˙200.00

Mappa

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 Obiettivo del progetto (Objective)

'When materials are implanted into the body they initiate an inflammatory response that is difficult to control. Consequently medical implants are tolerated by the body rather than fully integrated; the material is often sealed off from the body in a fibrotic capsule. Most recent research suggests that morphology is a decisive immunomodulatory trigger and may favor a healing-like reaction of the innate immune system, especially of macrophages.

I have pioneered a single-step method to generate non-woven fibrous scaffolds with surface chemistry control that allows specific cell adhesion. Additionally, my laboratory recently established melt electrospinning writing (MEW) that allows automated scaffold production by solvent-free electrostatic drawing with precise morphology control through rational deposition of polymer filaments in micrometer resolution.

Design2Heal is based on this world-wide unique combination of technologies and proposes to combine form (scaffold morphology) with function (surface chemistry) to generate biomaterials that are designed to heal and improve implant integration. Pioneering and ground breaking research within Design2Heal includes:

• A single-step procedure to fabricate MEW scaffolds with controlled surface functionalities for specific bioactivation.

• Unraveling the immunomodulatory potential of generic scaffold parameters (diameter, morphology) and surface functionalization (peptides, sugars, glycosaminoglycans) for rationally designed scaffolds in vitro with primary human innate immune cells.

• Resolve the immunomodulatory effects of cellular cross-talk and interaction between human immune cells, mesenchymal stem cells and endothelial progenitor cells in defined geometric confinements.

• In vivo proof-of-principle in the murine model In case of success, Design2Heal will be a ground breaking first step towards actively healing implants independently of the affected tissue, with tremendous impact on healthcare worldwide.'