PLANTMEDS

Potential Antimalarial and Anticancer Lead Compound Discovery from Cameroonian Medicinal Plants

Coordinatore	LIVERPOOL JOHN MOORES UNIVERSITY    more  Organization address address: Egerton Court Rodney Street 2 city: LIVERPOOL postcode: L3 5UX contact info Titolo: Mr. Nome: Ian Cognome: Pennington Email: send email Telefono: 441519000000
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	309˙235 €
EC contributo	309˙235 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IIF
Funding Scheme	MC-IIF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-11-01   -   2016-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	LIVERPOOL JOHN MOORES UNIVERSITY  Organization address address: Egerton Court Rodney Street 2 city: LIVERPOOL postcode: L3 5UX contact info Titolo: Mr. Nome: Ian Cognome: Pennington Email: send email Telefono: 441519000000	UK (LIVERPOOL)	coordinator	309˙235.20
2	UNIVERSITY OF WOLVERHAMPTON  Organization address address: WULFRUNA STREET city: WOLVERHAMPTON postcode: WV1 1LY contact info Titolo: Dr. Nome: Claire Cognome: Martin Email: send email Telefono: +441902 322149	UK (WOLVERHAMPTON)	participant	0.00

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 Obiettivo del progetto (Objective)

'Cameroon enjoys a rich biota including a plethora of medicinal plants, which have traditionally been used for hundreds of years to treat various ailments, and form the basis of the country’s primary healthcare system. Medicinal plants of the genera Fagara (F: Rutaceae), and Hannoa and Pierreodendron (F: Simaroubaceae) belong to the Cameroonian flora, and are used by the local people to treat malaria, cancer, rheumatism, bacterial infections, pain, inflammations, typhoid, skin infection and other serious disorders. Previous studies carried out on certain species of these genera afforded various phytochemicals (quassinoids, furoquinoleine, acridones, cathinone alcaloids, triterpenoids and steroids) and revealed interesting pharmacological properties (cytotoxicity, antiplasmadial activities). This project proposes to employ a combination of chemical fingerprinting-based dereplication, assay-guided fractionation and reversed-phase preparative high performance chromatographic methods to identify potential anticancer and antimalarial lead compounds from plants of the genera mentioned above, selected on the basis of ethnobotanical information as well as literature data. The structures of the isolated compounds will be elucidated by spectroscopic means (UV, IR, MS, NMR and X-ray). Structural modification to increase activity of compounds will be carried out applying modern semisynthetic approaches in order to establish structureactivity relationships. Total synthesis will also be carried out to increase to quantity of the lead compounds. Suitable in vitro bioassays, relevant to cytotoxicity, antimalarial and toxicity determination will be utilised to aid isolation processes as well as for the determination of bioactive potencies of the isolated lead compounds. The main objective is to discover and develop bioactive natural products and their analogues as clinical trial candidates.'