VISUALCIRCUITS

Dissecting the retinal inputs to behaviorally relevant computations in the central brain

Coordinatore	VIB    more  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: 3292446611 Fax: 3292446610
Nazionalità Coordinatore	Belgium [BE]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-06-01   -   2018-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	VIB  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: 3292446611 Fax: 3292446610	BE (ZWIJNAARDE - GENT)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'A key function of the visual system is to extract behaviourally relevant features about the visual scene from the barrage of incoming photons. This process begins in the retina, a powerful image processer that recent studies have revealed separates the incoming information into ~20 distinct neural representations. Within central visual brain regions specific details of the visual scene are often neatly organized, remaining spatially segregated from each other. Despite our detailed knowledge of how information is organized within the visual system, progress in gaining a mechanistic understanding of how the brain is able to extract salient features from the visual scene, or how this information is used to guide behavior has stalled. Too often each brain centre is studied in isolation, meaning the details of its inputs and function of its outputs are frequently a point of conjecture. In particular, the input to central visual areas, despite the accumulated evidence, are repeatedly assumed to simply be a relayed representation of the visual scene from the retina.

In order to provide mechanistic insight into how visual information is processed in central brain regions and understand how it is used to direct behavior this proposal will delineate the inputs, originating in the retina, to specific behavioural computations in central brain regions. This will allow us to determine which retinal channels are assigned dedicated computational tasks and how information from the retina is recombined to highlight key aspects of the visual scene used to direct behavior. To accomplish this conditional expression systems and trans-synaptic viral based circuit tracing will be combined with targeted patch-clamp recording and calcium imaging to link genetically identified cell types of the retina with behaviourally relevant computations in central brain regions. This work will provide insight into the circuit mechanisms used by the brain to process the visual world.'