CDH2_NEUROMIGRATION

The cytoskeleton and Cadherin-2 are tightly linked to coordinate nucleokinesis in migrating neurons

Coordinatore	TECHNISCHE UNIVERSITAT BRAUNSCHWEIG    more  Organization address address: POCKELSSTRASSE 14 city: BRAUNSCHWEIG postcode: 38106 contact info Titolo: Prof. Nome: Reinhard Cognome: Köster Email: send email Telefono: +49 5313913230 Fax: +49 531 3913222
Nazionalità Coordinatore	Germany [DE]
Totale costo	161˙968 €
EC contributo	161˙968 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IEF
Funding Scheme	MC-IEF
Anno di inizio	2015
Periodo (anno-mese-giorno)	2015-02-01   -   2017-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAT BRAUNSCHWEIG  Organization address address: POCKELSSTRASSE 14 city: BRAUNSCHWEIG postcode: 38106 contact info Titolo: Prof. Nome: Reinhard Cognome: Köster Email: send email Telefono: +49 5313913230 Fax: +49 531 3913222	DE (BRAUNSCHWEIG)	coordinator	161˙968.80

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 Obiettivo del progetto (Objective)

'The cerebellum coordinates the body’s movements. It consists of distinct layers of neuronal populations, but during embryonic development, these neurons are generated distantly from their final locations. In zebrafish, this means that cerebellar neurons have to migrate from the upper rhombic lip to the midbrain-hindbrain boundary and further. While descriptions of the migratory pathways for the different neuronal populations have become available in recent years, fundamental questions of this process are still unanswered. Firstly, we currently do not know how guidance of these cells is achieved and translated into directional motility. Activity could be a guiding cue, as it creates intracellular Ca2-transients which determine directionality in cerebellar neurons. Similarly, depletion of Cadherin-2, a cell-adhesion molecule and key regulator of cell migration, leads to loss of directionality. If activity works through Cadherin-2 to guide cells, it would present a novel way of transmitting information from outside to the inside of cells. We will test this notion using the latest genetic tools. Secondly, Cadherin-2 influences centrosome-positioning, yet we do not know the molecular mechanism of this. IQGAP1 could be the link between Caherin-2 and the microtubules, but this remains to be proven. Thirdly, in order to generate movement of the cells, the forces from the cytoskeleton need to be transmitted to the nucleus. Two models for such mechanisms are being debated, and we will test both in migrating cells in vivo. To address these questions, we will use an interdisciplinary approach combining techniques and knowledge from cell biology, developmental biology and genetics with advanced in vivo time-lapse imaging. Understanding how the cells’ migration is guided and regulated will improve the fundamental knowledge for the development of therapies for patients suffering from brain injuries or lissencephalies, and create a unique focus of cerebellar research in Europe.'