INSGEN

The incretin system: From genetic determinants to impact on early development of type 2 diabetes in the population

 Coordinatore KOBENHAVNS UNIVERSITET 

 Organization address postcode: 1017

contact info
Titolo: Mr.
Nome: Bjarne Friis
Cognome: Ploumark
Email: send email
Telefono: +45 35326346

 Nazionalità Coordinatore Denmark [DK]
 Totale costo 230˙809 €
 EC contributo 230˙809 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-03-01   -   2016-02-29

 Partecipanti

# participant  country  role  EC contrib. [€] 
1 KOBENHAVNS UNIVERSITET DK coordinator 230˙809.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

diabetes    tolerance    markers    glp    effect    incretin    levels    cohort    genetic    insulin    glucagon    oral    impaired    gip    prevention    stages    glucose    individuals   

 Obiettivo del progetto (Objective)

'The incretin hormones (GLP-1 and GIP) are secreted from the gut in response to food intake and their primary role is to amplify nutrient-induced insulin release. Most of this effect is lost in obesity and type 2 diabetes. Glucagon acts as a counter-regulatory hormone to insulin and may therefore also be essential in type 2 diabetes pathophysiology. My objective is to carry out a unique combination of state-of-the-art phenotyping and genotyping in a large, well-characterized cohort of people at key stages of increased diabetes risk. I will genotype a large panel of more than 500,000 genetic markers in 2,082 individuals with varying levels of glucose tolerance, either normal glucose tolerance, impaired fasting glycaemia, impaired glucose tolerance or type 2 diabetes. In addition, I will measure plasma levels of GLP-1, GIP and glucagon at 0, 30 and 120 minutes during an oral glucose tolerance test in the same individuals. I will then examine the effect of these genetic markers on incretin and glucagon levels during the oral glucose challenge. The results of the association study will be followed up in an additional cohort consisting of ~8,200 individuals from Sweden and Finland. The knowledge generated about the complex interplay of mechanisms driving the earliest stages of diabetes will allow identification of new potential targets for individualized prevention and treatment of type 2 diabetes. The epidemiological scale of the study will enable a direct translation of the findings to the real-life setting of population-wide general practice-based diabetes screening and tailored prevention.'

Altri progetti dello stesso programma (FP7-PEOPLE)

ILAND (2009)

A framework for individual-based forest landscape modeling under changing climate and disturbance regimes

Read More  

NGBOAN (2011)

Next-Generation Broadband Optical Access Networks

Read More  

OOCYTE ASYMMETRY (2010)

Quantitative dynamic analysis of homologous chromosome segregation and its coordination with the asymmetric meiotic division in live mouse oocytes

Read More