MENINGES-NET

Meninges: a new perivascular stem cells niche for widespread neurogenesis

 Coordinatore VIB 

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Mr.
Nome: Rik
Cognome: Audenaert
Email: send email
Telefono: 3292446611
Fax: 3292446610

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 235˙000 €
 EC contributo 235˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-03-01   -   2016-02-29

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    VIB

 Organization address address: Rijvisschestraat 120
city: ZWIJNAARDE - GENT
postcode: 9052

contact info
Titolo: Mr.
Nome: Rik
Cognome: Audenaert
Email: send email
Telefono: 3292446611
Fax: 3292446610

BE (ZWIJNAARDE - GENT) coordinator 235˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

neural    diseases    cells    stroke    angiogenesis    genetically    fate    differentiation    meningeal    stem    player    cell    cancer    neuro    neurovascular    brain    nsc    perivascular   

 Obiettivo del progetto (Objective)

'Adult neural stem cells (NSC) have been mainly described to be restricted within limited areas of the brain thought to be germinal remnants. However, new potential sites of NSCs activity have been recently described. The multiple locations of NSC niches, that increase in diseases, leaves open the question of whether and how these structures communicate throughout long distance. I and others have described a new player in the neurovascular unit: the perivascular meningeal stem cells. This cell population endow of neural differentiation potential and can migrate to the injured area contributing to brain parenchymal reaction following injury.

With this IEF, I will have the great opportunity to join the Neurovascular link lab of Prof P. Carmeliet, Leuven, Belgium, to investigate the hypothesis that a subtype of perivascular cells may contribute to neuro-angiogenesis both in health and disease.

I will address the following aims: (i) To genetically target perivascular meningeal stem cells. (ii) To understand the contribution of perivascular meningeal stem cells to neuro-angiogenesis in physiological and (iii) pathological conditions (stroke and cancer).

I will follow the fate of perivascular meningeal stem cells by gene fate mapping them combining several techniques, including mouse transgenesis, stereotactic viral vector transduction and in vivo plasmid electroporation. Moreover, I will investigate possible molecular mechanisms of stem cell differentiation by targeting relevant metabolic pathways. Finally, I will use laser induced photoactivated stroke and genetically knock-in/-out cancers as diseases animal models. This multidisciplinary approach will eventually shed the light to identify new player in the complex events occurring in endogenous neural regeneration and cancer. This experience will give me the chance to learn high impact research and to publish in top journals. This will dramatically improve my possibility to start an independent research career.'

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