MEMBRANE DYNAMICS
Role of Membrane Dynamics on Immunological Responses
| Coordinatore | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 221˙606 € |
| EC contributo | 221˙606 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2013-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2015 |
| Periodo (anno-mese-giorno) | 2015-01-13 - 2017-01-12 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | coordinator | 221˙606.40 |
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Obiettivo del progetto (Objective)
'The cellular plasma membrane is composed mainly of lipids and proteins. The bioactivity of the plasma membrane (such as the activation of receptors) is not only triggered and influenced by protein-protein or lipid-protein interactions, but also by bulk properties of the membrane such as the order or packing of lipids. In this project, I aim to understand how lipid packing influences membrane related processes in immunology such as T-cell signaling or antigen presentation. It is believed that lipid packing may have an important role in membrane-related immunological processes by concentrating various key molecules in a specific part of the membrane, thus constituting a catalytic platform to initiate signaling. However, numerous important questions remain, some of which I would like to pursue during my postdoctoral period using novel tools on model membranes and living cells: Is there any heterogeneity in lipid packing in the plasma membrane of T-cells or antigen-presenting (primary) cells? How does a variation in lipid packing effect the compartmentalization of key-proteins involved in T-cell signaling and antigen presentation, and how does this variation and compartmentalization effect functionality? Following that, I would like to develop an in-vitro lipid-protein vesicle system to model important characteristics of this aspect of immunology.'