NEUROHUBS

Functional diversity of single neurons in anatomically complex cortical networks

Coordinatore	THE HEBREW UNIVERSITY OF JERUSALEM.    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Israel [IL]
Totale costo	2˙000˙000 €
EC contributo	2˙000˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-CoG
Funding Scheme	ERC-CG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-10-01   -   2019-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Ms. Nome: Hani Cognome: Ben-Yehuda Email: send email Telefono: +972 2 6586676 Fax: +972 7 22447007	IL (JERUSALEM)	hostInstitution	2˙000˙000.00
2	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Prof. Nome: Adi Cognome: Mizrahi Email: send email Telefono: 97226586460 Fax: 97226584703	IL (JERUSALEM)	hostInstitution	2˙000˙000.00

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 Obiettivo del progetto (Objective)

'A fundamental quest in Neuroscience research is to reveal the function(s) of single neurons and networks. Understanding function seems to be on relatively solid grounds at the periphery where both anatomy and physiology converge in a simplified manner. However, as one ascends higher into the central nervous system, anatomy and physiology become increasingly more complex and functions become difficult to study. To reveal function, we will take a structure/function approach that synergizes between anatomical, physiological and behavioral methods. Namely, we will study the physiology of identified neurons to a rich set of stimuli bearing different behavioural contingencies and in the context of their anatomical boundaries. Specifically, my proposal aims to uncover function and structure of the mouse auditory cortex. First, we will redefine local and distant functional architecture in the auditory cortex using novel tracing techniques. Second, we will test a specific hypothesis whereas individual cortical neurons are multifunctional and part of distinct but multiple sub-networks. Third, we will use novel genetic techniques to tag and manipulate distinct cortical processing streams that are active during natural behaviors and specific learning paradigms. These experiments will answer whether specific sub-networks are instructive, permissive or necessary for perception. Finally, we will study how single neurons and sub-networks change in face of perceptual learning. As a whole, the main premise of this grant is to set the stage for, and eventually crystallize the experimental means to tease out functional diversity of single neurons in complex anatomical networks. Charting these basic principles for single neurons will impact how we study neuronal function and plasticity not only in the auditory system but across the mammalian brain.'