BRAIN STORM

On-chip simultaneous intracellular recording and stimulation of electrical and biochemical activities from hundreds of neurons

Coordinatore	INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW    more  Organization address address: KAPELDREEF city: LEUVEN postcode: 3001 contact info Titolo: Mrs. Nome: Christine Cognome: Van Houtven Email: send email Telefono: +32-16-281 613 Fax: +32-16-281 812
Nazionalità Coordinatore	Belgium [BE]
Totale costo	4˙241˙967 €
EC contributo	3˙200˙000 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2007-1
Funding Scheme	CP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-01-01   -   2010-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW  Organization address address: KAPELDREEF city: LEUVEN postcode: 3001 contact info Titolo: Mrs. Nome: Christine Cognome: Van Houtven Email: send email Telefono: +32-16-281 613 Fax: +32-16-281 812	BE (LEUVEN)	coordinator	0.00
2	PEPSCAN THERAPEUTICS BV  Organization address address: RUNDERWEG 4-6 city: LELYSTAD postcode: 8219 PK contact info Titolo: Mr. Nome: Nard Cognome: Langendijk Email: send email Telefono: -320237250 Fax: -320238089	NL (LELYSTAD)	participant	0.00
3	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: MT. SCOPUS city: JERUSALEM postcode: 91905 contact info Titolo: Dr. Nome: Eran Cognome: Vardi Email: send email Telefono: -6585706 Fax: -6512235	IL (JERUSALEM)	participant	0.00
4	UNIVERSITEIT TWENTE  Organization address address: DRIENERLOLAAN 5 city: ENSCHEDE postcode: 7522 NB contact info Titolo: Mr. Nome: B.J. Cognome: Pals Email: send email Telefono: -4893724 Fax: +31 53 4893114	NL (ENSCHEDE)	participant	0.00

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 Obiettivo del progetto (Objective)

In the BRAINSTORM project, we aim to develop an integrated system enabling on-chip intracellular recordings from a relatively large cultured neuronal network combined with chemical sensing and intracellular delivery of biologically active molecules. To achieve tight coupling with the cell membrane and enable efficient recordings, micronail-type probes will be integrated with a CMOS readout circuitry. These micronails are structured to operate either as intracellular microelectrodes or as intracellular micro-syringes allowing either chemical injection or to produce pressure or suction that will be used in additional to other procedures to penetrate the cell membrane. With appropriate bio-functionalization, the micro-nails inserted intracellularly will also serve as sensors for phosphorylation/ dephosphorylation reactions within living cells.nThe main technologies and methods to be developed in the BRAINSTORM project include:n•tBiocompatible and CMOS compatible micronails and micro-syringes with integrated readout electronics;n•tMicrofluidic system integrated with the CMOS-containing chip;n•tProcedures to insert both nail types through the plasma membrane, into the neuronal cytosole;n•tSurface chemistries allowing to achieve a Giga-Ohm (G) seal resistance between the disrupted plasma membrane and the nail;n•tHigh signal-to-noise ratio recordings of neuronal electrical activity with micronail probes;n•tOn-chip chemical delivery of chemicals;n•tOn-chip sensing of intracellular kinase activities.