BRAIN STORM
On-chip simultaneous intracellular recording and stimulation of electrical and biochemical activities from hundreds of neurons
| Coordinatore | INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW
Organization address
address: KAPELDREEF contact info |
| Nazionalità Coordinatore | Belgium [BE] |
| Totale costo | 4˙241˙967 € |
| EC contributo | 3˙200˙000 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2007-1 |
| Funding Scheme | CP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-01-01 - 2010-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW
Organization address
address: KAPELDREEF contact info |
BE (LEUVEN) | coordinator | 0.00 |
| 2 |
PEPSCAN THERAPEUTICS BV
Organization address
address: RUNDERWEG 4-6 contact info |
NL (LELYSTAD) | participant | 0.00 |
| 3 |
THE HEBREW UNIVERSITY OF JERUSALEM.
Organization address
address: MT. SCOPUS contact info |
IL (JERUSALEM) | participant | 0.00 |
| 4 |
UNIVERSITEIT TWENTE
Organization address
address: DRIENERLOLAAN 5 contact info |
NL (ENSCHEDE) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
In the BRAINSTORM project, we aim to develop an integrated system enabling on-chip intracellular recordings from a relatively large cultured neuronal network combined with chemical sensing and intracellular delivery of biologically active molecules. To achieve tight coupling with the cell membrane and enable efficient recordings, micronail-type probes will be integrated with a CMOS readout circuitry. These micronails are structured to operate either as intracellular microelectrodes or as intracellular micro-syringes allowing either chemical injection or to produce pressure or suction that will be used in additional to other procedures to penetrate the cell membrane. With appropriate bio-functionalization, the micro-nails inserted intracellularly will also serve as sensors for phosphorylation/ dephosphorylation reactions within living cells.nThe main technologies and methods to be developed in the BRAINSTORM project include:n•tBiocompatible and CMOS compatible micronails and micro-syringes with integrated readout electronics;n•tMicrofluidic system integrated with the CMOS-containing chip;n•tProcedures to insert both nail types through the plasma membrane, into the neuronal cytosole;n•tSurface chemistries allowing to achieve a Giga-Ohm (Gï—) seal resistance between the disrupted plasma membrane and the nail;n•tHigh signal-to-noise ratio recordings of neuronal electrical activity with micronail probes;n•tOn-chip chemical delivery of chemicals;n•tOn-chip sensing of intracellular kinase activities.