CARDIORISK
The mechanisms of cardiovascular risks after low radiation doses
| Coordinatore | KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Organization address
address: ISMANINGER STRASSE 22 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.cardiorisk.eu/ |
| Totale costo | 6˙701˙454 € |
| EC contributo | 2˙859˙897 € |
| Programma | FP7-EURATOM-FISSION
EURATOM: Nuclear fission and radiation protection |
| Code Call | FP7-Fission-2007 |
| Funding Scheme | CP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-02-01 - 2011-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Organization address
address: ISMANINGER STRASSE 22 contact info |
DE (MUENCHEN) | coordinator | 0.00 |
| 2 |
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O
Organization address
address: Oskar-von-Miller-Ring 29 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 3 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 4 |
INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
Organization address
address: Avenue de la Division Leclerc 31 contact info |
FR (FONTENAY AUX ROSES) | participant | 0.00 |
| 5 |
MARIA SKLODOWSKA-CURIE MEMORIAL CANCER CENTER
Organization address
address: "Ul.W.K. Roentgena, 5" contact info |
PL (WARZAWA) | participant | 0.00 |
| 6 |
QUEEN'S UNIVERSITY BELFAST
Organization address
address: University Road contact info |
UK (BELFAST) | participant | 0.00 |
| 7 |
SATEILYTURVAKESKUS
Organization address
address: Laippatie 4 contact info |
FI (HELSINKI) | participant | 0.00 |
| 8 |
STICHTING HET NEDERLANDS KANKER INSTITUUT
Organization address
address: PLESMANLAAN 121 contact info |
NL (AMSTERDAM) | participant | 0.00 |
| 9 |
TECHNISCHE UNIVERSITAET DRESDEN
Organization address
address: HELMHOLTZSTRASSE 10 contact info |
DE (DRESDEN) | participant | 0.00 |
| 10 |
THE UNIVERSITY OF SHEFFIELD
Organization address
address: FIRTH COURT WESTERN BANK contact info |
UK (SHEFFIELD) | participant | 0.00 |
| 11 |
UNIVERSITAET LEIPZIG
Organization address
address: RITTERSTRASSE 26 contact info |
DE (LEIPZIG) | participant | 0.00 |
| 12 |
UNIVERSITAET ROSTOCK
Organization address
address: UNIVERSITATSPLATZ 1 contact info |
DE (ROSTOCK) | participant | 0.00 |
| 13 |
UNIVERSITEIT MAASTRICHT
Organization address
address: Minderbroedersberg 4-6 contact info |
NL (MAASTRICHT) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular disease. In addition, radiation may increase atherosclerotic lesions in the coronary arteries. The aim of this collaborative research project is to elucidate the pathogenesis of early and late alteration in the microcirculation of the heart and of atherosclerotic lesions in arteries after exposure to low radiation doses in comparison to high radiation doses. A major goal will be the investigation of early molecular, proinflammatory and prothrombotic changes as well as perfusion alteration, cardiac cell integrity and immunologic influences. To achieve this goal, in vivo as well as ex vivo and in vitro studies will be performed. A central component of the project will be the local irradiation of the heart with subsequent isolation of cardiomyocytes and cardiac endothelial cells to provide all participating groups with the same biological material for further study. In addition, structural, morphological and molecular studies will be complemented by functional assays and imaging methods.'
Introduzione (Teaser)
Understanding the impact of radiation on cardiac function is vital for taking appropriate precautions to minimise exposure. The CARDIORISK initiative investigated the pathogenic mechanisms following radiation that affect myocardial perfusion and vascularisation, stress response and cardiac function.