PYTHIA

Monolithically Integrated Interferometric Biochips for label-free Early Detection of Human Diseases

Coordinatore	NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS"    more  Organization address address: End Patr. Grigoriou city: Ag. Paraskevi - Athens postcode: 15310 contact info Titolo: Ms. Nome: Styliani Cognome: Martaki Email: send email Telefono: 302107000000 Fax: 302107000000
Nazionalità Coordinatore	Greece [EL]
Totale costo	3˙519˙782 €
EC contributo	2˙650˙000 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2007-2
Funding Scheme	CP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-05-01   -   2011-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS"  Organization address address: End Patr. Grigoriou city: Ag. Paraskevi - Athens postcode: 15310 contact info Titolo: Ms. Nome: Styliani Cognome: Martaki Email: send email Telefono: 302107000000 Fax: 302107000000	EL (Ag. Paraskevi - Athens)	coordinator	0.00
2	JOBST TECHNOLOGIES GMBH  Organization address address: ENGESSERSTRASSE city: FREIBURG postcode: 79108 contact info Titolo: Mr. Nome: Gerhard Cognome: Jobst Email: send email Telefono: 497616000000 Fax: 497616000000	DE (FREIBURG)	participant	0.00
3	KENTRO GENNETIKON EREVNON KAI ANALYSEON A.E.  Organization address address: TECHNOLOGIKO PARKO ATTIKIS city: AGHIA PARASKEVI postcode: 15310 contact info Titolo: Mr. Nome: Vassilis Cognome: Tsopanas Email: send email Telefono: 302107000000 Fax: 302107000000	EL (AGHIA PARASKEVI)	participant	0.00
4	LIONIX BV  Organization address address: HALLENWEG city: ENSCHEDE postcode: 7522 NH contact info Titolo: Mr. Nome: Henk Cognome: Leeuwis Email: send email Telefono: 31534893827 Fax: +31 53 489 3601	NL (ENSCHEDE)	participant	0.00
5	PHOENIX BV  Organization address address: HENGELOSESTRAAT city: ENSCHEDE postcode: 7521PA contact info Titolo: Dr. Nome: Remco Cognome: Stoffer Email: send email Telefono: 31534836460 Fax: +31 53 4337415	NL (ENSCHEDE)	participant	0.00
6	TEKNOLOGIAN TUTKIMUSKESKUS VTT  Organization address address: Vuorimiehentie city: ESPOO postcode: 02044 VTT contact info Titolo: Ms. Nome: Mirka Cognome: Laasonen Email: send email Telefono: +358 20 722 4882 Fax: +358 20 7227012	FI (ESPOO)	participant	0.00
7	UNIVERSITY COLLEGE LONDON  Organization address address: Gower Street city: LONDON postcode: WC1E 6BT contact info Titolo: Ms. Nome: Greta Cognome: Borg-Carbott Email: send email Telefono: +44 2031083033 Fax: +44 20 78132849	UK (LONDON)	participant	0.00
8	UNIWERSYTET JAGIELLONSKI  Organization address address: Ul. Golebia city: KRAKOW postcode: 31007 contact info Titolo: Prof. Nome: Andrzej Cognome: Budkowski Email: send email Telefono: +48 12 663 55 50 Fax: +48 12 633 70 86	PL (KRAKOW)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

The proposed project aims at the development of a novel biochip based on monolithic, fully integrated biosensor array fabricated by standard Si-technology and its application to the early diagnosis of human diseases through label-free and multi-analyte detection.nThe basic sensor scheme consists of a VIS-NIR light source and a waveguide monolithically fabricated on a silicon wafer, while its principle of operation is the spectroscopic interference due to the optical path difference originating by biochemical events. The signal recording will be realized either via an also monolithically fabricated photodetector or via an external spectrophotometer. This dual approach will provide the user with higher flexibility in terms of the recording, since it will exploit both the intensity and spectral characteristics of the output signal. The integrated nature of the basic biosensor scheme allows for the development of arrays tailored to specific diagnostic applications. Each biosensor array will be comprised of individually functionalized light source/optical fiber series coupled to a single detector for multiplexing operation. Encapsulation with an appropriately designed microfluidic system will allow for the easy delivery of the samples to be analyzed and ensure the facile contact with the external low-noise electronic components. The encapsulated array will be fixed on a cartridge with all the necessary electronics, ready to be manually inserted to its final position in the housing, where it will be directly connected to the optical and electrical interconnects. The biochip, controlled by accompanying user-friendly software, will be capable of simultaneous multi-analyte detection (e.g. mutations of specific genes), and real-time monitoring and processing, with a detection duration that will not exceed a few minutes with minimal blood sample volumes or specimens.