MEMSTICK

Synaptic mechanisms of memory loss: novel cell adhesion molecules as therapeutic targets

Coordinatore	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE    more  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Carmen Cognome: Sandi Email: send email Telefono: +41 21 693 9534 Fax: +41 21 693 53 50
Nazionalità Coordinatore	Switzerland [CH]
Sito del progetto	http://www.memstick.org/
Totale costo	4˙138˙676 €
EC contributo	2˙970˙372 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-02-01   -   2011-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Carmen Cognome: Sandi Email: send email Telefono: +41 21 693 9534 Fax: +41 21 693 53 50	CH (LAUSANNE)	coordinator	0.00
2	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Nome: Mar Cognome: Garcia Ferrer Email: send email Telefono: 34 91 585 50 00 Fax: +34 91 411 3077	ES (MADRID)	participant	0.00
3	ENKAM PHARMACEUTICALS A/S  Organization address address: "Fruebjergvej, 3" city: COPENHAGEN postcode: 2100 contact info Titolo: Prof. Nome: Vladimir Cognome: Berezin Email: send email Telefono: +45-35 32 73 35 Fax: +45-39 17 97 14	DK (COPENHAGEN)	participant	0.00
4	INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK  Organization address address: UL. LUDWIKA PASTEURA 3 city: WARSZAWA postcode: 02 093 contact info Titolo: Dr. Nome: Marcin Cognome: Szumowski Email: send email Telefono: +48 22 589 22 63 Fax: +48 22 589 24 89	PL (WARSZAWA)	participant	0.00
5	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Ms. Nome: Tine Cognome: Heylen Email: send email Telefono: +32 16 326520 Fax: +31 16 326515	BE (LEUVEN)	participant	0.00
6	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Nome: Hartmut Cognome: Lingner Email: send email Telefono: +49 89 306 22330 Fax: +49 89 306 22372	DE (MUENCHEN)	participant	0.00
7	NEOLOCH PHARMACEUTICALS APS  Organization address address: Tjornekrogen 5 city: GENTOFTE postcode: 2820 contact info Titolo: Prof. Nome: Elisabeth Cognome: Bock Email: send email Telefono: 4526289456 Fax: 4535360116	DK (GENTOFTE)	participant	0.00
8	SCIPROM SARL  Organization address address: RUE DU CENTRE 70 city: Saint-Sulpice postcode: 1025 contact info Titolo: Dr. Nome: Kirsten Cognome: Leufgen Email: send email Telefono: +41 21 693 02 61 Fax: -	CH (Saint-Sulpice)	participant	0.00
9	THE OPEN UNIVERSITY  Organization address address: WALTON HALL city: MILTON KEYNES postcode: MK7 6AA contact info Titolo: Prof. Nome: Michael Cognome: Stewart Email: send email Telefono: +44-1908 653448 Fax: +44-1908 65417	UK (MILTON KEYNES)	participant	0.00

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 Obiettivo del progetto (Objective)

'Memory loss is a central symptom in different diseases, and represents a significant social and economic burden for a large percentage of European citizens. The molecular and neurobiological bases of memory deficits are largely unknown and there are currently no drugs available that can markedly decelerate or prevent memory decline. To address this major problem, this project will investigate the role of novel synaptic cell adhesion molecules (CAMs) in memory loss, and the therapeutic value of targeting these CAMs to restore memory function and associated neurobiological mechanisms at the synaptic level. The selection of novel synaptic CAMs is based on (1) recent evidence showing that they can recruit the synaptic machinery and form synapses; (2) the implication of CAMs, in general, in synaptic plasticity and memory, and (3) a direct link established between synaptic remodelling and memory formation. We have assembled a multidisciplinary consortium including excellent European researchers in this field, covering a wide range of structural, biochemical, electrophysiological and behavioural expertise. To understand memory loss, three domains have been selected as among the most prominent and widespread disease domains affecting memory and quality of life in our society: psychiatric disorders, the neurodegenerative disorder of Alzheimer's disease, stress and aging. For each disease domain, specific and validated animal models will be used to investigate memory loss on molecular, subcellular, cellular and functional levels. Our approach will result in the preclinical development and validation of mimetic peptides for novel synaptic CAMs as potential drug candidates to treat memory deficits or prevent memory decline. The current proposal offers the groundbreaking possibility to raise the bar in memory research by targeting novel molecules and developing effective drugs to treat memory disturbances based on their biological mechanism.'