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METAHIT

Metagenomics of the Human Intestinal Tract

Coordinatore	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Mr. Nome: François Cognome: Chambelin Email: send email Telefono: +33 1 42 75 93 74 Fax: +33 1 42 75 91 59
Nazionalità Coordinatore	France [FR]
Sito del progetto	http://www.metahit.eu/
Totale costo	21˙355˙988 €
EC contributo	11˙400˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-IP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-01-01 - 2012-06-30

Partecipanti

#	participant	country	role
1	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Mr. Nome: François Cognome: Chambelin Email: send email Telefono: +33 1 42 75 93 74 Fax: +33 1 42 75 91 59	FR (PARIS CEDEX 07)	coordinator
2	BEIJING GENOMICS INSTITUTE - CHINESE ACADEMY OF SCIENCES Organization address address: Beijing Airport Industrial Zone B6 city: BEIJING postcode: 101300 contact info Titolo: Prof. Nome: Huanming Cognome: Yang Email: send email Telefono: +86 10 80 49 11 81 Fax: +86 10 80 48 88 31	CN (BEIJING)	participant
3	Beijing Genomics Institute at Shenzhen Organization address address: Beishan Industrial Zone city: Shenzhen postcode: 518083 contact info Titolo: Prof. Nome: Huanming Cognome: Yang Email: send email Telefono: +86 755 25273796 Fax: +86 755 25273796	CN (Shenzhen)	participant
4	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 contact info Titolo: Dr. Nome: Jean Cognome: Weissenbach Email: send email Telefono: +33 1 60 87 25 02 Fax: +33 1 60 87 25 32	FR (PARIS 15)	participant
5	DANMARKS TEKNISKE UNIVERSITET Organization address address: Anker Engelundsvej 1, Building 101A city: KONGENS LYNGBY postcode: 2800 contact info Titolo: Ms. Nome: Karen Cognome: Bue Bitsch Email: send email Telefono: +45 45 25 75 20 Fax: +45 45 88 49 22	DK (KONGENS LYNGBY)	participant
6	DANONE RESEARCH Organization address address: Route Departementale 128 city: PALAISEAU postcode: 91767 contact info Titolo: Mr. Nome: Patrice Cognome: Lecoeuche Email: send email Telefono: +33 169357006 Fax: +33 169357699	FR (PALAISEAU)	participant
7	EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 contact info Titolo: Mr. Nome: Keith Cognome: Williamson Email: send email Telefono: +49 62213878295 Fax: +49 62213878211	DE (HEIDELBERG)	participant
8	GENOME RESEARCH LIMITED Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE contact info Titolo: Dr. Nome: Julian Cognome: Parkhill Email: send email Telefono: +44 1223 494902 Fax: +44 1223 494919	UK (LONDON)	participant
9	INSTITUT CATALA DE LA SALUT Organization address address: GRAN VIA DE LES CORTS CATALANES 587 city: BARCELONA postcode: 8007 contact info Titolo: Dr. Nome: Juan E. Cognome: Feliu Email: send email Telefono: +34 93 489 13 37 Fax: +34 93 489 41 02	ES (BARCELONA)	participant
10	ISTITUTO EUROPEO DI ONCOLOGIA SRL Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 contact info Titolo: Ms. Nome: Ilaria Cognome: Foti Email: send email Telefono: +39 0257 489 295 Fax: +39 0294 375 991	IT (MILANO)	participant
11	KOBENHAVNS UNIVERSITET	DK	participant
12	MERIEUX ALLIANCE SA Organization address address: RUE BOURGELAT 17 city: LYON postcode: 69002 contact info Titolo: Ms. Nome: Martine Cognome: Cattelain Email: send email Telefono: +33 4 78877074 Fax: +33 4 78877071	FR (LYON)	participant
13	NOVO NORDISK A/S Organization address address: NOVO ALLE 1 city: BAGSVAERD postcode: 2880 contact info Titolo: Prof. Nome: Oluf Cognome: Pedersen Email: send email Telefono: +45 44439050 Fax: +45 44438232	DK (BAGSVAERD)	participant
14	SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 contact info Titolo: Mr. Nome: Jens Cognome: Kierkegaard Email: send email Telefono: +45 6550 2911 Fax: +45 65 50 20 35	DK (ODENSE M)	participant
15	UCB PHARMA SA Organization address address: AVENIDA DE BARCELONA 239 city: MOLINS DE REI postcode: 8750 contact info Titolo: Ms. Nome: Ellen Cognome: Caldwell Email: send email Telefono: +34 93 680 34 01 Fax: +34 93 680 34 10	ES (MOLINS DE REI)	participant
16	WAGENINGEN UNIVERSITY Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB contact info Titolo: Prof. Nome: Willem Meindert Cognome: De Vos Email: send email Telefono: +31 317 482105 Fax: +31 317 483829	NL (WAGENINGEN)	participant

Mappa

Word cloud

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microbes tools metagenome genomes genome microorganisms disease genes human gene inflammatory obesity healthy gut creation microbiota individuals bowel health host sequencing public

Obiettivo del progetto (Objective)

'A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. Our proposal focuses on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We shall implement and integrate the following activities: (i) creation of a reference set of genes and genomes of intestinal microbes, using high fidelity metagenomic sequencing and full genome sequencing of selected bacterial species; (ii) creation of the generic tools, based on the high density DNA arrays and novel ultra-high throughput re-sequencing techniques, to study the variation of human gut microbiota; (iii) use of the tools to search for correlations between the genes present in the gut microbiota and disease, focusing on the inflammatory bowel disease and obesity, the two pathologies of increasing social relevance in Europe; (iv) study of the genes correlated with the disease, both in terms of their function in microbes and their effect on the host, with the focus on host-microbe interactions; (v) development of an informatics resource to store and organize the heterogeneous information generated within the project, such as gene and genome sequences, gene frequencies in healthy and sick individuals or gene functions and also enriched by information relevant to human gut microbiota from the outside of the project; (vi) creation of the bioinformatics tools to carry out the meta-analysis of the information; (vii) creation of an interface with the stakeholders, including an international board to promote cooperation and coordination in the human metagenome field, and general public. Our project will place Europe in a leading position in this field and open avenues to modulate human gut microbiota in a reasoned way, enabling to optimize the health and wellbeing of any individual.'

Introduzione (Teaser)

Inflammatory bowel diseases (IBDs) (e.g. ulcerative colitis (UC) and Crohn's disease (CD)) and obesity pose a rapidly growing challenge for public health services. The EU-funded project METAHIT has catalogued and assessed microbial genes present in the human gut to differentiate between diseased and healthy states in individuals.