SPINAL CORD REPAIR

Spinal locomotor circuits: organization and repair after injury

Coordinatore	KAROLINSKA INSTITUTET    more  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Therese Cognome: Sjöblom Email: send email Telefono: +46 8 524 87861 Fax: +46 8 333864
Nazionalità Coordinatore	Sweden [SE]
Sito del progetto	http://www.spinalcordrepair.eu/
Totale costo	3˙935˙200 €
EC contributo	2˙998˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-01-01   -   2011-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Therese Cognome: Sjöblom Email: send email Telefono: +46 8 524 87861 Fax: +46 8 333864	SE (STOCKHOLM)	coordinator	0.00
2	DANDO WEISS & COLUCCI LIMITED  Organization address address: LOWER BRISTOL ROAD MINERVA HOUSE city: BATH postcode: BA2 9ER contact info Titolo: Mr. Nome: Jeffrey Cognome: Dando Email: send email Telefono: 441179000000 Fax: -	UK (BATH)	participant	0.00
3	Novartis Forschungsstiftung  Organization address address: Maulbeerstrasse 66 city: BASEL postcode: 4058 contact info Titolo: Ms. Nome: Dorothy Cognome: Searles Email: send email Telefono: -6973002 Fax: -6973996	CH (BASEL)	participant	0.00
4	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Dawn Cognome: Barker Email: send email Telefono: +44 (0) 1223 333543 Fax: +44 (0) 1223 332988	UK (CAMBRIDGE)	participant	0.00
5	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Dr. Nome: Huub Cognome: Van Hedel Email: send email Telefono: +41 44 386 37 30 Fax: +41 44 386 37 31	CH (ZURICH)	participant	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Neural circuits in the spinal cord, called central pattern generators (CPGs), can produce locomotor movements. The locomotor activity pattern is the result of the circuit design and the interplay between the firing properties of the CPG constituent neurons and their synaptic interactions. Spinal cord injury impairs the function of the locomotor circuitry and results in paralysis. An understanding of the molecular mechanisms of the assembly of the spinal locomotor circuitry, the function of its key excitatory components and the intrinsic plasticity in the healthy and injured spinal cord is a prerequisite for designing novel therapeutic methods to restore locomotor function after spinal cord lesion. The work-packages have been designed to elucidate the key molecular pathways responsible for the development and assembly of the spinal circuitry for locomotion. The intrinsic function and modulation the spinal circuitry will be examined in the healthy spinal cord by combining sophisticated molecular, anatomical, pharmacological and electrophysiological tools. The mechanisms of plasticity and reorganization of the circuitry will be examined in the injured spinal cord as will the mechanism to promote regeneration of the lesioned axons. This project will integrate knowledge on the development and normal spinal cord function together with biological interventions aiming at protecting and repairing the injured spinal cord. The gained understanding will offer molecular and cellular foundations that will be instrumental in developing strategies for restoring motor function following spinal cord injury.'

Introduzione (Teaser)

Spinal cord injury (SCI) or dysfunction can impair or cause movement and/or sensation loss, chronic pain and other dysfunctions. The SPINAL CORD REPAIR project is a multidisciplinary collaboration among EU scientists to reinstate motor function or movement after spinal cord injuries.