DEER

Developmental effects of environment on reproductive health

Coordinatore	TURUN YLIOPISTO    more  Organization address address: YLIOPISTONMAKI city: TURUN YLIOPISTO postcode: 20014 contact info Titolo: Dr. Nome: Eliisa Cognome: Särkilahti Email: send email Telefono: +358 2 3336155 Fax: +358 2 3336446
Nazionalità Coordinatore	Finland [FI]
Totale costo	4˙615˙781 €
EC contributo	3˙499˙028 €
Programma	FP7-ENVIRONMENT Specific Programme "Cooperation": Environment (including Climate Change)
Code Call	FP7-ENV-2007-1
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-05-01   -   2012-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TURUN YLIOPISTO  Organization address address: YLIOPISTONMAKI city: TURUN YLIOPISTO postcode: 20014 contact info Titolo: Dr. Nome: Eliisa Cognome: Särkilahti Email: send email Telefono: +358 2 3336155 Fax: +358 2 3336446	FI (TURUN YLIOPISTO)	coordinator	0.00
2	DANMARKS TEKNISKE UNIVERSITET  Organization address address: Anker Engelundsvej 1, Building 101A city: KONGENS LYNGBY postcode: 2800 contact info Titolo: Ms. Nome: Karen Cognome: Bue Bitsch Email: send email Telefono: +45 4525 7520 Fax: +45 4588 4922	DK (KONGENS LYNGBY)	participant	0.00
3	ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE  Organization address address: Site de la Chantrerie, Route de Gachet city: NANTES postcode: 44307 contact info Titolo: Ms. Nome: Celine Cognome: Raoul Email: send email Telefono: +33 2 40 68 78 80 Fax: +33 2 40 68 78 78	FR (NANTES)	participant	0.00
4	INSTITUTE OF EXPERIMENTAL MORPHOLOGY AND ANTHROPOLOGY WITH MUSEUM- BAS  Organization address address: "AKAD G BONCHEV STREET, BLOCK 25" city: SOFIA postcode: 1113 contact info Titolo: Prof. Nome: Yordan Cognome: Yordanov Email: send email Telefono: +359 2 8706547 Fax: +359 2 871 90 07	BG (SOFIA)	participant	0.00
5	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Ms. Nome: Patricia Cognome: Young Email: send email Telefono: +44 1312426241 Fax: +44 1312426197	UK (SWINDON)	participant	0.00
6	RIGSHOSPITALET  Organization address address: Blegdamsvej 9 city: KOEPENHAGEN postcode: 2100 contact info Titolo: Mr. Nome: Joergen Cognome: Joergensen Email: send email Telefono: +45 3545 5566 Fax: +45 3545 6528	DK (KOEPENHAGEN)	participant	0.00
7	UNIVERSIDAD DE CORDOBA  Organization address address: AVENIDA DE MEDINA AZAHARA 5 city: CORDOBA postcode: 14005 contact info Titolo: Prof. Nome: Enrique Cognome: Aguilar Benitez De Lugo Email: send email Telefono: +34 957 21 8989 Fax: +34 957 21 8998	ES (CORDOBA)	participant	0.00
8	UNIVERSITE DE RENNES I  Organization address address: RUE DU THABOR 2 city: RENNES CEDEX postcode: 35065 contact info Titolo: Ms. Nome: Yolaine Cognome: Bompays Email: send email Telefono: +33 223233723 Fax: +33 223235876	FR (RENNES CEDEX)	participant	0.00
9	UNIVERSITY OF ROCHESTER  Organization address address: "ELMWOOD AVENUE, BOX EHSC 601" city: ROCHESTER NY postcode: 14642 contact info Titolo: Ms. Nome: Marlene Cognome: Boutet Email: send email Telefono: +1 585 273 3960 Fax: +1 585 275 9492	US (ROCHESTER NY)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'The multidisciplinary research teams in this consortium have played lead roles in establishing that fetal and childhood periods are vulnerable to environmental disruption leading to common reproductive disorders. This proposal will investigate: (1) connections between normal/abnormal perinatal reproductive development and maturation of reproductive function at puberty and in adulthood; (2) systemic gene-environment interactions underlying reproductive disorders taking account of genetic susceptibility, multiple exposures (e.g. mixtures of environmental chemicals) and their timing (perinatal, peripubertal, adult); (3) connection between perinatal reproductive development and later obesity/metabolic disorders. To achieve this we will utilize large cohorts generated in previous EU projects and collect new data from these on reproductive maturation and adult function. Existing genomic and proteomics data, exposure data for >100 potentially toxic environmental chemicals, lifestyle, dietary and medical history information will be analysed using integrative systems biology approaches to pinpoint critical (interacting) factors influencing development. Established animal models will be used to test putative mechanisms by analysing the roles of neuroendocrine regulation, intrauterine growth, time windows of reproductive development, metabolic balance and xenobiotic metabolism. Toxicogenomics, proteomics and metabolomics results from these studies will identify pathways for study in the human cohorts. The overall aim is to create new cause-effect frameworks and knowledge networks to refine research in this critical area and to identify novel biomarkers of exposure and disease. The proposed studies will facilitate prediction and prevention of reproductive disorders and provide large new datasets and exposure-outcome information to improve environmental risk assessment and risk management.'

Introduzione (Teaser)

An EU-funded project aimed to elucidate the possible link between male reproductive health problems and developmental (foetal and neonatal) exposure to common environmental chemicals.