LUPA
Unravelling the molecular basis of common complex human disorders using the dog as a model system
| Coordinatore | UNIVERSITE DE LIEGE
Organization address
city: LIEGE contact info |
| Nazionalità Coordinatore | Belgium [BE] |
| Sito del progetto | http://www.eurolupa.org/ |
| Totale costo | 15˙677˙376 € |
| EC contributo | 11˙997˙994 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-A |
| Funding Scheme | CP-IP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-01-01 - 2012-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITE DE LIEGE
Organization address
city: LIEGE contact info |
BE (LIEGE) | coordinator | 0.00 |
| 2 |
ANIMAL HEALTH TRUST
Organization address
address: "Lanwades Hall, Lanwades Park" contact info |
UK ("Kentford, Newmarket") | participant | 0.00 |
| 3 |
ANTAGENE
Organization address
address: "ALLEE DES SEQUOIAS 2, IMMEUBLE LE MELTEM" contact info |
FR (LIMONEST) | participant | 0.00 |
| 4 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 0.00 |
| 5 |
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Organization address
address: RUE LEBLANC 25 contact info |
FR (PARIS 15) | participant | 0.00 |
| 6 |
ECOLE NATIONALE VETERINAIRE D'ALFORT
Organization address
address: Avenue du General de Gaulle 7 contact info |
FR (MAISONS-ALFORT) | participant | 0.00 |
| 7 |
HELSINGIN YLIOPISTO
Organization address
address: YLIOPISTONKATU 4 contact info |
FI (HELSINGIN YLIOPISTO) | participant | 0.00 |
| 8 | KOBENHAVNS UNIVERSITET | DK | participant | 0.00 |
| 9 |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address
address: GESCHWISTER SCHOLL PLATZ 1 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 10 |
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Organization address
address: UNIVERSITETSTUNET 3 contact info |
NO (AS) | participant | 0.00 |
| 11 |
NORGES VETERINAERHOGSKOLE
Organization address
address: Ullevaalsveien 72 contact info |
NO (OSLO) | participant | 0.00 |
| 12 |
SVERIGES LANTBRUKSUNIVERSITET
Organization address
address: ARRHENIUSPLAN 4 contact info |
SE (UPPSALA) | participant | 0.00 |
| 13 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 0.00 |
| 14 |
THE ROYAL VETERINARY COLLEGE
Organization address
address: Royal College Street contact info |
UK (LONDON) | participant | 0.00 |
| 15 |
THE UNIVERSITY OF LIVERPOOL
Organization address
address: Brownlow Hill, Foundation Building 765 contact info |
UK (LIVERPOOL) | participant | 0.00 |
| 16 |
THE UNIVERSITY OF MANCHESTER
Organization address
address: OXFORD ROAD contact info |
UK (MANCHESTER) | participant | 0.00 |
| 17 |
THE UNIVERSITY OF NOTTINGHAM
Organization address
address: University Park contact info |
UK (NOTTINGHAM) | participant | 0.00 |
| 18 |
UNIVERSITAET BERN
Organization address
address: Hochschulstrasse 4 contact info |
CH (BERN) | participant | 0.00 |
| 19 |
UNIVERSITAET ZUERICH
Organization address
address: Raemistrasse 71 contact info |
CH (ZURICH) | participant | 0.00 |
| 20 |
UNIVERSITAT AUTONOMA DE BARCELONA
Organization address
address: Campus UAB -BELLATERRA- s/n contact info |
ES (CERDANYOLA DEL VALLES) | participant | 0.00 |
| 21 |
UNIVERSITEIT UTRECHT
Organization address
address: Heidelberglaan 8 contact info |
NL (UTRECHT) | participant | 0.00 |
| 22 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Organization address
address: BELFIELD contact info |
IE (DUBLIN) | participant | 0.00 |
| 23 |
UPPSALA UNIVERSITET
Organization address
address: SANKT OLOFSGATAN 10 B contact info |
SE (UPPSALA) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Despite major efforts, identifying susceptibility genes for common human diseases - cancer, cardiovascular, inflammatory and neurological disorders - is difficult due to the complexity of the underlying causes. The dog population is composed of ~ 400 purebred breeds; each one is a genetic isolate with unique characteristics resulting from persistent selection for desired attributes or from genetic drift / inbreeding. Dogs tend to suffer from the same range of diseases than human but the genetic complexity of these diseases within a breed is reduced as a consequence of the genetic drift and – due to long-range linkage disequilibrium – the number of SNP markers needed to perform whole genome scans is divided by at least ten. Here, we propose a European effort gathering experts in genomics to take advantage of this extraordinary genetic model. Veterinary clinics from 12 European countries will collect DNA samples from large cohorts of dogs suffering from a range of thoroughly defined diseases of relevance to human health. Once these different cohorts will be built, DNA samples will be sent to a centralized, high-throughput SNP genotyping facility. The SNP genotypes will be stored in central database and made available to participating collaborating centres, who will analyze the data with the support of dedicated statistical genetics platforms. Following genome wide association and fine-mapping candidate genes will be followed up at the molecular level by expert animal and human genomics centers. This innovative approach using the dog model will ultimately provide insights into the pathogenesis of common human diseases – its primary goal.'
Introduzione (Teaser)
Identifying genetic information on illnesses in dogs may help find cures for serious illnesses such as cancer, as well as cardiovascular, inflammatory and neurological disorders.
Descrizione progetto (Article)
Studying common human diseases such as cancer or cardiovascular disorders from a genetic perspective can yield much-needed information about how to properly diagnose and treat them. A particular field in genetics - called genomics - focuses on mapping or 'sequencing' the genes or DNA implicated in these diseases. Because the human genome is quite complicated, it is often easier and quicker to study the genome of dogs, who also suffer from similar diseases. Man's best friend is generally less complex genetically than humans, and less samples are needed to derive meaningful information.
The LUPA project is unravelling the molecular basis of common human disorders using the dog as a model system. It is studying genetic factors both in purebred dogs and in mixed breeds for more efficient localisation of key genetic factors.
The main goal of LUPA is to identify genes and mutations that account for the high incidence of certain diseases in specific dog breeds. The culprit genes are identified by looking at the entire gene mapping sequence of dogs - or their genome - using what's known as genome-wide association studies (GWAS). Genetic material is being identified for five different categories of illnesses: cancers, cardiovascular disorders, inflammatory disorders, neurological disorders and monogenic disorders (those caused by a mutation in a single gene). Altogether, the LUPA project is performing genome-wide scans on over 10,000 dogs.
There are 20 veterinary clinics in 12 European countries working together to collect DNA samples required for the different project partners. Collection and characterisation of samples is a formidable task and has taken over two years. Almost all samples have been collected, with the involvement of kennels, breeders, veterinarians and owners.
Overall, since the project kicked off more than 7,000 samples have been collected and processed. Promising results are already emerging for two monogenic diseases, and similar genes in humans have been identified. Moreover, genome areas in dogs have been identified for other more complex disorders such as epilepsy, cancers, cardiovascular diseases and inflammatory disorders.
In addition to providing new insights regarding prognosis and treatment of human diseases, LUPA could have a major impact on the future of veterinary medicine in Europe.