ARTEMIP

THE SAFETY PHARMACOLOGY OF ARTEMISININS WHEN USED TO REVERSE PATHOPHYSIOLOGY OF MALARIA IN PREGNANCY

Coordinatore	LIVERPOOL SCHOOL OF TROPICAL MEDICINE    more  Organization address address: Pembroke Place city: LIVERPOOL postcode: L35QA contact info Titolo: Prof. Nome: Stephen Cognome: Ward Email: send email Telefono: +44 151 705 3286 Fax: +44 151 705 3371
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙597˙331 €
EC contributo	1˙948˙880 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-03-01   -   2011-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	LIVERPOOL SCHOOL OF TROPICAL MEDICINE  Organization address address: Pembroke Place city: LIVERPOOL postcode: L35QA contact info Titolo: Prof. Nome: Stephen Cognome: Ward Email: send email Telefono: +44 151 705 3286 Fax: +44 151 705 3371	UK (LIVERPOOL)	coordinator	0.00
2	GOETEBORGS UNIVERSITET  Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Prof. Nome: Michael Cognome: Ashton Email: send email Telefono: +46 31 786 3412 Fax: +46 31 786 3284	SE (GOETEBORG)	participant	0.00
3	THE UNIVERSITY OF LIVERPOOL  Organization address address: Brownlow Hill, Foundation Building 765 city: LIVERPOOL postcode: L69 7ZX contact info Titolo: Ms. Nome: Veronica Cognome: Cannings Email: send email Telefono: +44 151 794 8722 Fax: +44 151 794 8728	UK (LIVERPOOL)	participant	0.00
4	UNIVERSIDADE DO ALGARVE  Organization address address: CAMPUS DE PENHA city: FARO postcode: 8005 139 contact info Titolo: Prof. Nome: Maria De Lurdes Cognome: Cristiano Email: send email Telefono: +35 1298 800 900 Fax: +35 1289 800 066	PT (FARO)	participant	0.00
5	UNIVERSITEIT LEIDEN  Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2300 RA contact info Titolo: Mr. Nome: Ton Cognome: Bouw Er Email: send email Telefono: +31 71 527 3149 Fax: +31 71 527 5269	NL (LEIDEN)	participant	0.00
6	WORLD HEALTH ORGANIZATION.  Organization address address: Avenue Appia 20 city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Piero Cognome: Olliaro Email: send email Telefono: +41 22 791 3734 Fax: +41 22 791 4774	CH (GENEVE)	participant	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Artemisinin based antimalarial drug combinations are recommended for the treatment of P.falciparum malaria infections throughout all malarial endemic areas of the world and in all populations, including women of child bearing age. The studies planned in this collaborative project are central to assessing the potential hazard posed by these drugs to the developing human foetus and thereby making evidence based recommendations on the risk:benefit of these drugs. Although clinical experience to date indicates the artemisinins to be safe, the area of reproductive toxicology demands special consideration. Data from the Chinese literature and our own studies confirm that the artemisinins are embryotoxic and potentially teratogenic in animal species at drug doses within the human therapeutic range. Based on over ten years of investigating the pharmacology of these drugs we have developed a hypothesis which can explain these teratogenic effects. Our hypothesis is based on the generation of reactive oxygen species (ROS) from cleavage of the artemisinin peroxide bridge and consequent embryofoetal damage to key biological macromolecules. Our hypothesis draws on parallels with the metabolic activation and teratogenic effects of the other established teratogens such as phenytoin'