CARS EXPLORER

"Innovative contrast imaging by non-linear optics (NLO) for the observation of biological tissues in vivo and in real time, at cellular and molecular levels"

Coordinatore	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)    more  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Mr. Nome: Dominique Cognome: Nobile Email: send email Telefono: -91826976 Fax: -91742038
Nazionalità Coordinatore	France [FR]
Totale costo	4˙701˙881 €
EC contributo	3˙091˙129 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-03-01   -   2011-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Mr. Nome: Dominique Cognome: Nobile Email: send email Telefono: -91826976 Fax: -91742038	FR (PARIS)	coordinator	0.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Béatrice Cognome: Saint-Cricq Email: send email Telefono: -91163979 Fax: -91779275	FR (PARIS)	participant	0.00
3	DE DUVE INSTITUTE  Organization address address: "Avenue Hippocrate 75, ICP 75.50" city: BRUXELLES postcode: 1200 contact info Titolo: Mr. Nome: Philippe Cognome: Penninckx Email: send email Telefono: 32 2 764 75 88 Fax: 32 2 764 75 73	BE (BRUXELLES)	participant	0.00
4	INSERM - TRANSFERT SA  Organization address address: Rue Watt 7 city: PARIS postcode: 75013 contact info Titolo: Mr. Nome: Louis Cognome: Jammayrac Email: send email Telefono: -55030069 Fax: -55030128	FR (PARIS)	participant	0.00
5	MAUNA KEA TECHNOLOGIES  Organization address address: 10 rue d'Enghien city: PARIS postcode: 75010 contact info Titolo: Ms. Nome: Caroline Cognome: Garnier Email: send email Telefono: -48240535 Fax: -48241186	FR (PARIS)	participant	0.00
6	UNIVERSITAET STUTTGART  Organization address address: Keplerstrasse 7 city: STUTTGART postcode: 70174 contact info Titolo: Ms. Nome: Dorothee Cognome: Schettler Email: send email Telefono: +49-711-685 65277 Fax: +49-711-685 65281	DE (STUTTGART)	participant	0.00
7	UNIVERSITY OF BATH  Organization address address: CLAVERTON DOWN city: BATH postcode: BA2 7AY contact info Titolo: Mr. Nome: Peter Cognome: Hompstead Email: send email Telefono: 44 1225 394490 Fax: 44 1225 383276	UK (BATH)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'The CARS EXPLORER seeks to demonstrate the concept of innovative light-based contrasting technologies for functional in situ imaging in life science and biomedical research. Our ultimate goal is to develop an endoscope based on non-linear optics (NLO) and laser pulse phase shaping. Non linear laser pulse interactions with living tissues provide unique possibilities, such as an absence of sample preparation, direct multiparametric visualization with molecular specificity and cellular resolution, and deep sample penetration. Nevertheless, the effective transfer of NLO to biomedical applications faces major technological challenges related to the delivery of ultra-short laser pulses, the weakness of the signal produced in biological samples and the difficulty in interpreting generated contrasts. Therefore, the CARS EXPLORER interdisciplinary consortium includes partners with expertise ranging from optical physics to the clinic. The work plan is split into 5 RTD workpackages: three are intended to overcome specific technological problems with (1) the development of dedicated methodology using phase shaping for NLO imaging of deep biological tissues, (2) the development of specific photonic crystal fibre optics for the excitation, delivery and collection of NLO signals, and (3) the extraction of relevant information from NLO signals generated in biological tissues. The two other workpackages will determine the assets and constraints in NLO imaging through appropriate experimental biological models. These models will also assess each technological improvement made on the microscope and endoscope prototypes. Last, to bring the concept to the diagnostic level, we will explore the molecular and morphological NLO signatures associated with tumor development in skin cancer. In addition to the challenge of developing pulse shaped NLO-based endoscope technology, this project will have strategic and economic impact by providing a non-invasive functional exploration method.'

Introduzione (Teaser)

The early detection of diseases, such as developing tumours, can reduce mortality significantly. The EU-funded CARS EXPLORER project aimed to develop non-linear optics (NLO) technology that can provide, in real-time, minimally invasive disease diagnosis at cellular and molecular levels.