TB-VIR
Mycobacterium tuberculosis W-Beijing genetic diversity and differential virulence and host immune responses
| Coordinatore |
Organization address
address: Rue Michel -Ange 3 contact info |
| Nazionalità Coordinatore | Non specificata |
| Totale costo | 3˙887˙442 € |
| EC contributo | 2˙967˙000 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2007-A |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-04-01 - 2011-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | coordinator | 0.00 |
| 2 |
"RUJIN HOSPITAL, SHANGAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE"
Organization address
address: 197 RUI JIN ER ROAD contact info |
CN (SHANGHAI) | participant | 0.00 |
| 3 |
FUDAN UNIVERSITY
Organization address
address: HANDAN ROAD 220 contact info |
CN (SHANGHAI) | participant | 0.00 |
| 4 |
GATC BIOTECH AG
Organization address
address: JAKOB STADLER PLATZ 7 contact info |
DE (KONSTANZ) | participant | 0.00 |
| 5 |
INSERM - TRANSFERT SA
Organization address
address: Rue Watt 7 contact info |
FR (PARIS) | participant | 0.00 |
| 6 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | participant | 0.00 |
| 7 |
INSTITUT PASTEUR KOREA
Organization address
address: "HAWOLGOK DONG, SEONGBUK GU 39-1" contact info |
KR (SEOUL) | participant | 0.00 |
| 8 |
INTEGRAGEN SA
Organization address
address: RUE HENRI DESBRUERES GENOPOLE 5 contact info |
FR (EVRY) | participant | 0.00 |
| 9 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 10 |
SHANGAI MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION
Organization address
address: west Zhongshan Road contact info |
CN (SHANGAI) | participant | 0.00 |
| 11 |
UNIVERSIDAD DE ZARAGOZA
Organization address
address: CALLE PEDRO CERBUNA 12 contact info |
ES (Zaragoza) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Improvements in TB control require the development of new tools for rapid and accurate diagnosis and intervention. This development is likely to benefit from more detailed knowledge of microbe-host relationships during infection. Following M. tuberculosis infection, only 5-10% of immunocompetent individuals develop TB. It is increasingly thought that the virulence of the infecting strain, together with host genetic factors, contribute to such differences between infected individuals. The M. tuberculosis W-Beijing lineage is one of the most successful mycobacterial families, in terms of morbidity and mortality. This lineage has been detected almost worldwide. The predominance of the W-Beijing lineage probably results from genetic advantages, including unidentified virulence factors and the induction/modification of specific host responses not yet thoroughly investigated. This project aims to unravel the links between differential host responses to M. tuberculosis infection and mycobacterial genetic diversity and virulence at the global genomic and post-genomic levels within the W-Beijing family, and between the W-Beijing family and other M. tuberculosis families, in order to improve our understanding of the epidemiological success of this particular lineage. Overall, this work will provide the scientific and clinical community with pioneering research and novel information increasing our understanding of the impact of M. tuberculosis strain diversity on virulence, immune response and pathology. This project will complement and expand the efforts of several internationally recognized laboratories to unveil new genotype-phenotype associations by integrating complex phenotypic data and information about mycobacterial genetic diversity.'
Introduzione (Teaser)
Tuberculosis (TB) remains a serious health issue worldwide with nearly 1.7 million related deaths every year. The urgent requirement for intervention drove researchers of the TB-VIR project to study the genetics of Mycobacterium tuberculosis (MTB) virulence.