TB-VIR

Mycobacterium tuberculosis W-Beijing genetic diversity and differential virulence and host immune responses

Coordinatore	more  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Armelle Cognome: Barelli Email: send email Telefono: +33 5 61 33 60 80 Fax: +33 5 62 17 29 01
Nazionalità Coordinatore	Non specificata
Totale costo	3˙887˙442 €
EC contributo	2˙967˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-01   -   2011-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Armelle Cognome: Barelli Email: send email Telefono: +33 5 61 33 60 80 Fax: +33 5 62 17 29 01	FR (PARIS)	coordinator	0.00
2	"RUJIN HOSPITAL, SHANGAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE"  Organization address address: 197 RUI JIN ER ROAD city: SHANGHAI postcode: 200025 contact info Titolo: Ms. Nome: Yiping Cognome: Xu Email: send email Telefono: 8621-64370045 ext 665824 Fax: 8621-64333414	CN (SHANGHAI)	participant	0.00
3	FUDAN UNIVERSITY  Organization address address: HANDAN ROAD 220 city: SHANGHAI postcode: 200433 contact info Titolo: Prof. Nome: Xue-Lei Cognome: Lin Email: send email Telefono: 8621-65642484 Fax: 8621-65649267	CN (SHANGHAI)	participant	0.00
4	GATC BIOTECH AG  Organization address address: JAKOB STADLER PLATZ 7 city: KONSTANZ postcode: 78467 contact info Nome: Peter Cognome: Pohl Email: send email Telefono: +49-(0)7531-8160-13 Fax: +49-(0)7531-8160-81	DE (KONSTANZ)	participant	0.00
5	INSERM - TRANSFERT SA  Organization address address: Rue Watt 7 city: PARIS postcode: 75013 contact info Titolo: Mr. Nome: Louis Cognome: Jammayrac Email: send email Telefono: -55030069 Fax: -55030128	FR (PARIS)	participant	0.00
6	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Nadia Cognome: Khelef Email: send email Telefono: +33 1 40 61 33 78 Fax: +33 1 40 61 39 40	FR (PARIS CEDEX 15)	participant	0.00
7	INSTITUT PASTEUR KOREA  Organization address address: "HAWOLGOK DONG, SEONGBUK GU 39-1" city: SEOUL postcode: 136 791 contact info Titolo: Ms. Nome: Sungeun Cognome: Kim Email: send email Telefono: -3511 Fax: -3429	KR (SEOUL)	participant	0.00
8	INTEGRAGEN SA  Organization address address: RUE HENRI DESBRUERES GENOPOLE 5 city: EVRY postcode: 91000 contact info Titolo: Mr. Nome: Patrick Cognome: Court Email: send email Telefono: +33 160 910 909 Fax: +33 160 910 922	FR (EVRY)	participant	0.00
9	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Birgit Cognome: Gieding Email: send email Telefono: +49-30-28460 125 Fax: +49-30-28460 242	DE (MUENCHEN)	participant	0.00
10	SHANGAI MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION  Organization address address: west Zhongshan Road city: SHANGAI postcode: 200336 contact info Nome: Hangping Cognome: Yang Email: send email Telefono: +86 21 62758710 Fax: x	CN (SHANGAI)	participant	0.00
11	UNIVERSIDAD DE ZARAGOZA  Organization address address: CALLE PEDRO CERBUNA 12 city: Zaragoza postcode: 50009 contact info Titolo: Mr. Nome: Oscar Cognome: Lopez Lorente Email: send email Telefono: 34976761000 Fax: 34976761048	ES (Zaragoza)	participant	0.00

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 Obiettivo del progetto (Objective)

'Improvements in TB control require the development of new tools for rapid and accurate diagnosis and intervention. This development is likely to benefit from more detailed knowledge of microbe-host relationships during infection. Following M. tuberculosis infection, only 5-10% of immunocompetent individuals develop TB. It is increasingly thought that the virulence of the infecting strain, together with host genetic factors, contribute to such differences between infected individuals. The M. tuberculosis W-Beijing lineage is one of the most successful mycobacterial families, in terms of morbidity and mortality. This lineage has been detected almost worldwide. The predominance of the W-Beijing lineage probably results from genetic advantages, including unidentified virulence factors and the induction/modification of specific host responses not yet thoroughly investigated. This project aims to unravel the links between differential host responses to M. tuberculosis infection and mycobacterial genetic diversity and virulence at the global genomic and post-genomic levels within the W-Beijing family, and between the W-Beijing family and other M. tuberculosis families, in order to improve our understanding of the epidemiological success of this particular lineage. Overall, this work will provide the scientific and clinical community with pioneering research and novel information increasing our understanding of the impact of M. tuberculosis strain diversity on virulence, immune response and pathology. This project will complement and expand the efforts of several internationally recognized laboratories to unveil new genotype-phenotype associations by integrating complex phenotypic data and information about mycobacterial genetic diversity.'

Introduzione (Teaser)

Tuberculosis (TB) remains a serious health issue worldwide with nearly 1.7 million related deaths every year. The urgent requirement for intervention drove researchers of the TB-VIR project to study the genetics of Mycobacterium tuberculosis (MTB) virulence.