ONCOMIRS

MicroRNAs and Cancer: From Bench to Bedside

Coordinatore	VIB    more  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Wim Cognome: Goemaere Email: send email Telefono: 3292446611 Fax: 3292446610
Nazionalità Coordinatore	Belgium [BE]
Sito del progetto	http://med.kuleuven.be/cme-mg/oncomirs/index.html
Totale costo	4˙278˙007 €
EC contributo	2˙992˙227 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-02-01   -   2013-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	VIB  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Wim Cognome: Goemaere Email: send email Telefono: 3292446611 Fax: 3292446610	BE (ZWIJNAARDE - GENT)	coordinator	0.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Armelle Cognome: Barelli Email: send email Telefono: + 33 5 61 33 60 80 Fax: + 33 562 17 29 01	FR (PARIS)	participant	0.00
3	EXIQON A/S  Organization address address: Bygstubben 9 city: VEDBAEK postcode: 2950 contact info Titolo: Dr. Nome: Søren Vestergaard Cognome: Rasmussen Email: send email Telefono: 4545650934 Fax: +45 4565 1888	DK (VEDBAEK)	participant	0.00
4	FUNDACIO CENTRE DE REGULACIO GENOMICA  Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 contact info Titolo: Ms. Nome: Elisenda Cognome: Folch Email: send email Telefono: +34 93 316 0108 Fax: + 34 93 396 9983	ES (BARCELONA)	participant	0.00
5	KOBENHAVNS UNIVERSITET	DK	participant	0.00
6	UNIVERSITAET REGENSBURG  Organization address address: UNIVERSITAETSSTRASSE 31 city: REGENSBURG postcode: 93053 contact info Titolo: Dr. Nome: Christian Cognome: Blomeyer Email: send email Telefono: -4144 Fax: -3380	DE (REGENSBURG)	participant	0.00
7	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Talia Cognome: Tzahor Email: send email Telefono: -3996 Fax: -12543	IL (REHOVOT)	participant	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Although studies addressing their role in cancer pathogenesis are at an early stage, it is apparent that specific microRNAs (miRs) and molecules involved in their biogenesis contribute to tumorigenesis. The ONCOMIRS consortium proposes a natural succession of four experimental strategies. Fist, we will DISCOVER and unveil novel miRs and components of their biogenesis machinery and investigate links between these molecules and human cancers. Secondly, we will CONNECT the information obtained on deregulated miRs with known cellular pathways involved in cancer, such as the p53 tumour suppressor pathway. This will be conducted using both forward experimentations, in which targets mRNA are experimentally identified for a number of miR aetiologically related to cancer, and reverse experimentations in which mouse models and cell lines with abrogated tumour suppressor pathways or activated oncogenes are used. To establish a causal relationship between dysregualted miRs and cancer development we will MODEL the tumorigenic processes in mice lacking or overexpressing particular miRs. Finally, since the specificity and potency of some miRs suggest that they might be promising as THERAPEUTIC agents, these models will be used in conjunction with other cancer models to explore miR-based therapeutic strategies.'