O-PTM-BIOMARKERS

Discovery of novel cancer serum biomarkers based on aberrant post translational modifications of O-glycoproteins (O-PTM-Biomarkers) and their application to early detection of cancer

Coordinatore	KING'S COLLEGE LONDON    more  Organization address address: Strand city: LONDON postcode: WC2R 2LS contact info Titolo: Mr. Nome: Paul Cognome: Labbett Email: send email Telefono: +44-(0)20-78488184 Fax: +44-(0)20-78488187
Nazionalità Coordinatore	United Kingdom [UK]
Sito del progetto	http://www.clrc.rhul.ac.uk/o-ptm/
Totale costo	3˙847˙340 €
EC contributo	2˙848˙153 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-01-01   -   2011-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON  Organization address address: Strand city: LONDON postcode: WC2R 2LS contact info Titolo: Mr. Nome: Paul Cognome: Labbett Email: send email Telefono: +44-(0)20-78488184 Fax: +44-(0)20-78488187	UK (LONDON)	coordinator	0.00
2	ANTIGONE LTD  Organization address address: Highpoint Business Village city: ASHFORD postcode: YN24 8DH contact info Titolo: Prof. Nome: Joyce Cognome: Taylor-Papadimitriou Email: send email Telefono: +44(0)1442 862614 Fax: +44(0)1442 385641	UK (ASHFORD)	participant	0.00
3	IPATIMUP - INSTITUTO DE PATOLOGIA EIMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP  Organization address address: RUA DR ROBERTO FRIAS SN city: PORTO postcode: 4200 465 contact info Titolo: Ms. Nome: Ana Sofia Cognome: Silva Email: send email Telefono: -5570371 Fax: -5570470	PT (PORTO)	participant	0.00
4	KLINIKUM DER UNIVERSITAET ZU KOELN  Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 contact info Titolo: Ms. Nome: Jutta Cognome: Landvogt Email: send email Telefono: +49-(0)221-4785204 Fax: +49-(0)221-47845543	DE (KOELN)	participant	0.00
5	KOBENHAVNS UNIVERSITET	DK	participant	0.00
6	ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE  Organization address address: EGHAM HILL UNIVERSITY OF LONDON city: EGHAM postcode: TW20 0EX contact info Titolo: Ms. Nome: Susan Cognome: Angulatta Email: send email Telefono: +44-(0)1784-443019 Fax: +44-(0)1784-475309	UK (EGHAM)	participant	0.00
7	THYMED GMBH  Organization address address: Mikroforum Ring 2 city: WENDELSHEIM postcode: 55234 contact info Titolo: Dr. Nome: Peter Cognome: Trinder Email: send email Telefono: +49-(0)6734-911800 Fax: +49-(0)6734-911833	DE (WENDELSHEIM)	participant	0.00
8	TRANSGENE SA  Organization address address: BOULEVARD GONTHIER D ANDERNACH - PARC D'INNOVATION city: ILLKIRCH-GRAFFENSTADEN postcode: 67405 contact info Titolo: Mr. Nome: Philippe Cognome: Poncet Email: send email Telefono: -88279092 Fax: -882791681	FR (ILLKIRCH-GRAFFENSTADEN)	participant	0.00
9	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Mr. Nome: Michael Cognome: Browne Email: send email Telefono: +44(-0)20-76796135 Fax: +44-(0)20-73806929	UK (LONDON)	participant	0.00

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 Obiettivo del progetto (Objective)

'Early detection accomplished through an efficient screening programme remains the most promising approach to improve the long-term survival of cancer patients. Therefore there is a pressing need for the development of biomarkers, which detect the early changes for cancers where clinical symptoms only appear when the cancer has progressed, and treatment is ineffective. Our proposal, which addresses this problem at the European level, combines two unique features: i) large unique collections of sera with the potential for evaluation of diagnostic serum biomarkers with high statistical power, and ii) a novel technological approach involving specific immuno-detection of cancer-associated Post-Translationally Modified (PTM) glycoproteins in serum and of auto-antibodies to these glycoproteins. Glycosylation of proteins is one of the most abundant and complex forms of post translation modifications and the most important for the cell surface and secreted proteomes. O-glycosylation (O-PTM) is always altered in carcinomas, creating novel O-PTM epitopes which induce auto-antibodies. Our Main Objectives are therefore to:- 1.Use a novel glycopeptide microarray technology to identifiy, evaluate and validate an O-PTM auto-antibody signature as an early diagnostic biomarker, focusing on breast, ovarian, pancreatic and lung cancers. 2. Develop and validate novel ELISA-type assays for cancer specific glycoforms of the MUC1 and MUC16 glycoproteins (targets of current serum biomarker assays). The project brings together a Consortium with participants from 5 member States to fully exploit the potential of the unique serum banks at a European level by A. Integrating the expertise of world leaders in Glycobiology with Cancer Physicians and experts in biomarker assays. B. Establishing a functional interaction between Academic groups and Commercial enterprises committed to improving cancer therapy and diagnosis.'