FAST

Fiber optic activation of serotonergic terminals during olfactory discrimination

 Coordinatore FUNDACAO CALOUSTE GULBENKIAN 

 Organization address address: AVENIDA DE BERNA 45A
city: LISBOA
postcode: 1000

contact info
Titolo: Dr.
Nome: Zachary
Cognome: Mainen
Email: send email
Telefono: -214464182
Fax: -214407619

 Nazionalità Coordinatore Portugal [PT]
 Totale costo 92˙077 €
 EC contributo 92˙077 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-2-1-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-10-16   -   2010-10-15

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN

 Organization address address: AVENIDA DE BERNA 45A
city: LISBOA
postcode: 1000

contact info
Titolo: Dr.
Nome: Zachary
Cognome: Mainen
Email: send email
Telefono: -214464182
Fax: -214407619

PT (LISBOA) coordinator 0.00

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olfactory    afferents    ht    neurons    serotonergic    sensory    central    directly   

 Obiettivo del progetto (Objective)

'In the central nervous system, 5-hydroxytryptamine (5-HT, or serotonin) acts as a neuromodulator and is synthetized by a specific population of neurons. 5-HT is released in nearly all subdivisions of the CNS and is involved in a wide array of brain functions as well as in several disorders. Although current hypotheses regarding the role of central 5-HT remain wide-ranging, a prominent view has progressively emerged from previous studies. A primary function of 5-HT might be to dampen sensory information processing while facilitating motor output. This 'sensorimotor gating' hypothesis is supported by indirect evidence and has never been tested directly. This proposal aims at investigating the influence of 5-HT on olfactory performance. By using mice expressing a recently developed light-gated cation channel (Channelrhodopsin-2) in serotonergic neurons, we will be able to excite serotonergic afferents to the olfactory bulb through a fiber optic interface. Using this innovative method, we will interfere with the native modulation pattern of these afferents during olfactory discrimination. The effects of this manipulation will be assessed directly at the behavioral level. This novel experimental paradigm offers tremendous improvements compared to previous ones and is expected to provide unprecedented insights into the role of central 5-HT in sensory processing.'

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