STSGA

Statistical Tools for studying genetic architecture

Coordinatore	UNIVERSITETET I OSLO    more  Organization address address: Problemveien 5-7 city: OSLO postcode: 313 contact info Titolo: Dr. Nome: Maren S. Rasch Cognome: Onsrud Email: send email Telefono: -22854376 Fax: -22854679
Nazionalità Coordinatore	Norway [NO]
Totale costo	189˙689 €
EC contributo	189˙689 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-01   -   2009-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITETET I OSLO  Organization address address: Problemveien 5-7 city: OSLO postcode: 313 contact info Titolo: Dr. Nome: Maren S. Rasch Cognome: Onsrud Email: send email Telefono: -22854376 Fax: -22854679	NO (OSLO)	coordinator	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Molecular biology has shown that most phenotypes are affected by complex, interacting gene networks. Yet, evolutionary biologists and population geneticists often assume very simple genetic architectures where genes act more of less independently of each other. These assumptions are made for conceptual clarity and are partially justified through statistical definitions of gene effects that capture the main effects of alleles as averages over many complex interactions. Still, recent research has revealed many systematic patterns of epistasis and pleiotropy with population genetic effects that should not be ignored. This makes a detailed understanding of genetic architecture important for many questions in evolutionary biology, including the basis of evolvability, and also instrumental for many questions in animal and crop improvement, including our ability to predict selection limits and to avoid unwanted side effects of artificial selection. The philosophy of this project is to develop methods that yield operational measurements of dynamically relevant parameters. A serious problem is the study of genetic architecture has been that many of the parameters in use are not derived from process models, epistatic variance components being the most obvious example. For this reason, it is necessary to combine the statistical models with process models to ensure a general understanding of the meaning of estimators.'

Introduzione (Teaser)

Novel software packages have the power to tease out genetic interactions and genetic architecture much more accurately than the current state of the art.