CHLAMITRNA

Dissecting the cytosolic tRNA import process in mitochondria of the unicellular green alga Chlamydomonas reinhardtii

Coordinatore	UNIVERSITE DE LIEGE    more  Organization address city: LIEGE postcode: 4000 contact info Titolo: Prof. Nome: Claire Cognome: Remacle Email: send email Telefono: 3243663812 Fax: -3243663840
Nazionalità Coordinatore	Belgium [BE]
Totale costo	164˙319 €
EC contributo	164˙319 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-15   -   2010-04-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE LIEGE  Organization address city: LIEGE postcode: 4000 contact info Titolo: Prof. Nome: Claire Cognome: Remacle Email: send email Telefono: 3243663812 Fax: -3243663840	BE (LIEGE)	coordinator	0.00

Mappa

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 Obiettivo del progetto (Objective)

'During evolution, plant mitochondrial genomes underwent multiple rearrangements leading to the loss of genetic information. One of the consequences is that the number of mitochondrial encoded tRNA genes is not sufficient to ensure plant mitochondrial translation. In order to compensate this deficiency, cytosolic tRNAs have to be imported into mitochondria. Although this phenomenon is an essential process for mitochondrial biogenesis in most eukaryotic cells, it remains poorly understood. The unicellular green alga Chlamydomonas represents an attractive model organism for the study of this mechanism. There is a high and selective import of cytosolic tRNA into mitochondria and the manipulation of the nuclear and mitochondrial genomes is possible. One of the goals of the project pertains the comprehension of the regulation of this process inside mitochondria. For this, we will manipulate the mitochondrial genome of Chlamydomonas reinhardtii in order to measure the effect on the balance of imported and non-imported tRNAs. A second major aim is to determine the role of the components of the tRNA import machinery in C. reinhardtii and thus we plan to selectively inactivate the expression of the corresponding genes by RNA silencing.'

Introduzione (Teaser)

Mitochondria are organelles found in almost all eukaryotic cells. The cells of eukaryotic organisms have complex membrane-bound structures, such as the nucleus, and other organelles such as chloroplasts, which capture light energy through photosynthesis.