STRUCTURAL DYNAMICS

New science for European ps time-resolved Laue X-ray diffraction

Coordinatore	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙000˙000 €
EC contributo	1˙000˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2007-StG
Funding Scheme	ERC-SG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-12-01   -   2012-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Dr. Nome: Jasper J. Cognome: Van Thor Email: send email Telefono: 020-75945071	UK (LONDON)	hostInstitution	0.00
2	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Brooke Cognome: Alasya Email: send email Telefono: +44 207 594 1181 Fax: +44 207 594 1418	UK (LONDON)	hostInstitution	0.00

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 Obiettivo del progetto (Objective)

'I pursue the study of molecular reaction dynamics of biomolecules mostly in the non-coherent time-regime using spectroscopic and X-ray structural techniques. In recent years, breakthroughs in the field of pump-probe X-ray crystallographic structure determination of reaction intermediates of light-sensitive proteins have generated much excitement. These experiments provide insight of key Biological importance and marry structural observations with spectroscopic studies to understand molecular reactivity. My work focuses on the light-sensitive proteins in particular to provide structural dynamics understanding of photoreactions and Biological signalling. The European Synchrotron Radiation Facility is investing in this area, providing and integrating technology that has been developed for pump-probe experiments using the pink-Laue technique in new designs for an upgraded and advanced beamline at ESRF. Historically, research groups in the US have dominated this field and the recent commissioning of the Biocars pump-probe beamline 14-ID-B at APS which has capabilities similar to ID09B at ESRF shows that international competition is strong. While technical capabilities of these two sources have rapidly developed, there has been an obvious lag in applications for the methodology. So far, photolysis of heme proteins (myoglobin-CO and recently FixL) and a photoreceptor molecule called Photoactive Yellow Protein (PYP) have been targets for pump-probe experiments. Clearly it is of strong strategic importance for European science to compete in this area. I have invested four years to develop the Green Fluorescent Protein as a new application, focussing on both time-resolved Laue diffraction as well as ultrafast vibrational and visible spectroscopy to characterise structural dynamics and to establish excited state absorption properties and reactivity for optical pulse profile optimisation for providing sufficient optical penetration. Here, I request European support for establi'