ASMENA
Functional assays for membrane protein on nanostructured supports
| Coordinatore | EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
| Nazionalità Coordinatore | Switzerland [CH] |
| Sito del progetto | http://www.asmena.ethz.ch/ |
| Totale costo | 5˙435˙545 € |
| EC contributo | 3˙940˙098 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2007-SMALL-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-09-01 - 2011-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
CH (ZUERICH) | coordinator | 0.00 |
| 2 |
CHALMERS TEKNISKA HOEGSKOLA AB
Organization address
address: - contact info |
SE (GOETEBORG) | participant | 0.00 |
| 3 |
EOTVOS LORAND TUDOMANYEGYETEM
Organization address
address: EGYETEM TER 1-3 contact info |
HU (BUDAPEST) | participant | 0.00 |
| 4 |
F. HOFFMANN-LA ROCHE AG
Organization address
address: GRENZACHERSTRASSE 124 contact info |
CH (BASEL) | participant | 0.00 |
| 5 |
Farfield Group Limited
Organization address
address: CHICAGO AVENUE WEST WING LEVEL 7 contact info |
UK (MANCHESTER) | participant | 0.00 |
| 6 |
HYDROGENE AB
Organization address
address: MARTENS FALAD 102 contact info |
SE (LUND) | participant | 0.00 |
| 7 |
Layerlab AB
Organization address
address: STENA CENTER 1D contact info |
SE (GOTEBORG) | participant | 0.00 |
| 8 |
LEISTER PROCESS TECHNOLOGIES*
Organization address
address: GALILEO-STRASSE 10 contact info |
CH (KAGISWIL) | participant | 0.00 |
| 9 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 10 |
MIKROVAKUUM MIKROELEKTRONIKAI ES VAKUUMTECHNIKAL KFT
Organization address
address: KEREKGYARTO U 10 contact info |
HU (BUDAPEST) | participant | 0.00 |
| 11 |
PAUL SCHERRER INSTITUT
Organization address
address: Villigen contact info |
CH (VILLIGEN PSI) | participant | 0.00 |
| 12 |
SuSoS AG
Organization address
address: LAGERSTRASSE 14 contact info |
CH (DUBENDORF) | participant | 0.00 |
| 13 |
UNIVERSITE BORDEAUX I
Organization address
address: 351 Cours de la Liberation contact info |
FR (TALENCE) | participant | 0.00 |
| 14 |
UNIVERSITEIT TWENTE
Organization address
address: DRIENERLOLAAN 5 contact info |
NL (ENSCHEDE) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'More than 50% of all drug targets are membrane proteins; new research tools to screen function of membrane drug targets are therefore expected to open up new avenues for original drug development. The proposed project addresses the need of the pharmaceutical industry for new technologies for reliable and efficient screening of membrane proteins as drug targets. Most critical current aspects of membrane protein assays are (a) the lack of reliable procedures to immobilize membrane proteins on sensor surfaces in a format suitable for label-free high-throughput screening of drug candidates; (b) the need for downscaling assay formats to accelerate functional screening; and (c) the feasibility of reading out the diverse functions of membrane proteins. The partners – with highly complementary expertise and experience of working together – will develop platforms for functional membrane protein assays by integration of the most recently gained knowledge and techniques. The key concepts of the platforms include (a) exploitation of nanoporous substrates to enhance the stability of supported proteolipid membranes and their integration in a sensor chip format; (b) nanoscale surface modifications for directed self-assembly of proteolipid structures on chip; and (c) self-assembly of proteolipid membranes onto nano-sized sensor structures from proteoliposomes, and demonstration of the functionality in quantitative drug candidate screening assays suitable for commercial applications. The project is expected to make a substantial contribution to (a) improved understanding of lipid membrane and membrane protein interaction with designed nanoenvironments; (b) development of prototype products and intellectual property related to membrane protein sorting and handling; (c) new compounds for functionalization of biosensor applications; (d) cost-effective array-based concepts for nanoplasmonic and electrochemical sensing; and (e) functional assays for membrane protein drug targets.'
Introduzione (Teaser)
Testing drugs can be a long drawn out and expensive process. A European project is aiming to remedy this by incorporating cell components and drugs on trial onto a biosensor chip.