SHEEPMILKGENES

High resolution mapping of a QTL region influencing fat percentage in Spanish Churra dairy sheep

Coordinatore	UNIVERSIDAD DE LEON    more  Organization address address: "Avenida de la Facultad, 25" city: LEON postcode: 24071 contact info Titolo: Dr. Nome: Juan Jose Cognome: Arranz Email: send email Telefono: -292423 Fax: -242264
Nazionalità Coordinatore	Spain [ES]
Totale costo	45˙000 €
EC contributo	45˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-2-ERG
Funding Scheme	MC-ERG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-01   -   2011-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSIDAD DE LEON  Organization address address: "Avenida de la Facultad, 25" city: LEON postcode: 24071 contact info Titolo: Dr. Nome: Juan Jose Cognome: Arranz Email: send email Telefono: -292423 Fax: -242264	ES (LEON)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Dairy sheep production in Mediterranean countries is based on the regional exploitation of a great variety of breeds, whose milk is processed into high quality cheese. The maintenance of these local breeds is strategically important from genetic diversity and environmental perspectives. Modern molecular genetics tools can be used to increase the efficiency of classic breeding programs in dairy sheep. Previously to the development of effective marker- or gene-assisted protocols, it was necessary to identify the genes controlling the production traits considered as selection targets. This project will increase the density of genetic markers at a QTL region influencing milk fat percentage in a commercial population of Churra sheep, a Spanish indigenous breed highly specialized in milk production. A combined linkage analysis and linkage disequilibrium analysis will subsequently be applied to refine the QTL position, enabling the identification of positional and functional candidate genes included in the refined QTL region. The strongest candidate genes and also inter-genic regions will be characterised further by sequence analysis for SNP discovery. The allelic variants identified will then be tested for possible relationships with milk fat percentage. This project will represent the first attempt to move genetic mapping in DAIRY sheep, from low-density linkage studies to high-density linkage disequilibrium and association methods. The project will take advantage of the information derived from the latest release of the Bovine Genome sequence (comparative approach) and the Virtual Sheep Genome sequence. This is a novel approach to gene identification in dairy sheep, which has only just become possible with the increased available information on the sheep and cattle genomes. The successful fulfilment of the project objectives may lead to the implementation of molecular information into the classic breeding program currently running in the Churra population.'

Introduzione (Teaser)

European research is combining the benefits of genomics and more conventional genetics in the breeding programmes of ancient Iberian Churra sheep. The work promises to increase the nutritional value of sheep dairy products, particularly protein and fat content.