MEIOSYS

Systematic analysis of factors controlling meiotic recombination in higher plants

Coordinatore	THE UNIVERSITY OF BIRMINGHAM    more  Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT contact info Titolo: Mr. Nome: Robert Cognome: Fekete Email: send email Telefono: 441214000000 Fax: 441214000000
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	6˙223˙215 €
EC contributo	4˙499˙920 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2007-2A
Funding Scheme	CP-IP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-07-01   -   2014-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF BIRMINGHAM  Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT contact info Titolo: Mr. Nome: Robert Cognome: Fekete Email: send email Telefono: 441214000000 Fax: 441214000000	UK (BIRMINGHAM)	coordinator	1˙243˙872.00
2	UNIVERSITAT WIEN  Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 contact info Titolo: Dr. Nome: Peter Cognome: Schloegelhofer Email: send email Telefono: 431428000000 Fax: 43142779562	AT (WIEN)	participant	676˙390.00
3	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Mr. Nome: Moctar Cognome: Diaby Email: send email Telefono: +33 1 30 83 31 00 Fax: +33 1 30 83 32 27	FR (PARIS CEDEX 07)	participant	571˙380.00
4	THE SCOTTISH CROP RESEARCH INSTITUTE  Organization address address: "ERROL ROAD, INVERGOWRIE" city: DUNDEE postcode: DD2 5DA contact info Titolo: Dr. Nome: Neil Cognome: Hattersley Email: send email Telefono: 441383000000 Fax: 441383000000	UK (DUNDEE)	participant	455˙262.00
5	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Domenico Cognome: Pignone Email: send email Telefono: 39805583400 Fax: 39805587566	IT (ROMA)	participant	355˙716.00
6	UNIVERSIDAD COMPLUTENSE DE MADRID  Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 contact info Titolo: Ms. Nome: Maribel Cognome: Rodriguez Email: send email Telefono: 34913946376 Fax: 34913946382	ES (MADRID)	participant	325˙890.00
7	FORSCHUNGSINSTITUT FUER MOLEKULARE PATHOLOGIE Ges.m.b.H  Organization address address: Dr. Bohr-Gasse 7 city: VIENNA postcode: 1030 contact info Titolo: Ms. Nome: Tanja Cognome: Winkler Email: send email Telefono: +431797 303613 Fax: +431798 71 53	AT (VIENNA)	participant	311˙202.00
8	STICHTING KATHOLIEKE UNIVERSITEIT  Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ contact info Titolo: Prof. Nome: Tom Cognome: Gerats Email: send email Telefono: +3124 3652910 Fax: +3124 3652490	NL (NIJMEGEN)	participant	306˙480.00
9	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Michèle Cognome: Saumon Email: send email Telefono: 33169823272 Fax: 33169823333	FR (PARIS)	participant	253˙728.00
10	THE JAMES HUTTON INSTITUTE  Organization address address: ERROL ROAD INVERGOWRIE city: DUNDEE postcode: DD2 5DA contact info Titolo: Mrs. Nome: Karen Cognome: Robb Email: send email Telefono: 441383000000	UK (DUNDEE)	participant	0.00

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 Obiettivo del progetto (Objective)

'Meiotic recombination has underpinned plant breeding for the generation of new traits of agronomic, environmental and economic importance, although we still have little understanding of the controlling mechanisms involved in this process. We will combine approaches in genomics and systems biology to obtain a detailed understanding of the factors that control recombination and will provide a basis for the development of strategies to modify recombination in a variety of crop species.'

Introduzione (Teaser)

As the world population continues to grow, it becomes even more essential that there are enough crops to maintain the food supply. In an EU-funded project, scientists are manipulating the meiotic process in three crops to explore how genomics can help maintain food security.

Descrizione progetto (Article)

Meiosis is a process of cell division used by both plants and animals to produce gametes (sperm and eggs) for reproduction. Not only does the process ensure that the correct number of chromosomes are passed on, it also mixes the genes from previous generations to create genetic variation within a species.

This project, 'Systematic analysis of factors controlling meiotic recombination in higher plants' (MEIOSYS) changed events in meiosis in certain plants to create greater genetic variety, increase food production, and ensure food security.

Using genetics and bioinformatics, scientists focused on the plants Arabidopsis, brassicas, and the cereal crop barley. During the first phase of the project, scientists set up a database to share data on plant experiments.

With the goal of identifying genes controlling crossover frequency, investigators then used the gene AtFANCM1, which had shown promise as a crossover regulator, to study the barley plant. This work led to the discovery of FANCM helicase, the first gene that may alter recombination patterns. Scientists are currently generating more plants to monitor these patterns. To date, three additional genes have been discovered.

The next phase of the project involves transferring knowledge of meiosis to crop species. Using barley and brassicas, scientists targeted the SPO11 gene to monitor recombination events at specific genomic locations.

Today, plants are at the heart of the European food industry. Although intensive breeding has boosted plants' yield, quality, and resistance to stress, current predictions suggest that over the next 50 years, population growth and climate changes will result in the need for even greater quantities of food By applying genomics and systems biology to food production, scientists hope to maximise genetic variability, ensuring high-quality food for the 21st century.