'RIBOSOME MM'

A Synthetic Molecular Machine Capable of Complex Task Performance: Processive Sequence-Selective Synthesis

Coordinatore	THE UNIVERSITY OF EDINBURGH    more  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 650 9023
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	0 €
EC contributo	172˙434 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-03-01   -   2011-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 650 9023	UK (EDINBURGH)	coordinator	172˙434.64

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 Obiettivo del progetto (Objective)

'The aim of this proposal is to synthesize and demonstrate the successful operation of one of the first synthetic molecular machines capable of performing a complex task at the molecular level. The target is to mimic translation, the process through which protein is synthesized on the mRNA template in the ribosome. To achieve this ambitious task (in a very basic form) through the action of a wholly artificial molecular machine system we propose to utilize a [2]rotaxane in which the macrocycle component acts as both a catalyst and a molecular transporter, abstracting bulky aromatic amino acid substituents from a sequence-specific ‘thread’ and transporting them in turn to the next amino acid fragment before mediating the formation of a new amide bond between them. The design is such that the macrocycle is forced to approach each amino acid in sequence, and is unable to pass until the cycle is complete, imparting sequential integrity to the oligopeptide synthesis. The mechanically interlocked nature of the rotaxane ensures processivity during the machine’s operation. Although biology uses threaded molecular architectures to transfer chemical information during sequence-specific oligomer and polymer assembly (proteins, oligo- and polysaccharides, DNA and RNA), such effects are unprecedented in artificial systems. We hope that our synthetic studies will provide a breakthrough in the development of artificial molecular machines that can perform real tasks at the molecular level including, ultimately, the synthesis of unnatural sequence-specific oligomers and polymers that are not accessible by other routes.'