POLYPHOSPHATE
"Inorganic Polyphosphate: Synthesis and Functions, relationship with Inositol Polyphosphates"
| Coordinatore | MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 236˙620 € |
| EC contributo | 236˙620 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2007-2-1-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-07-01 - 2011-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | coordinator | 0.00 |
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Obiettivo del progetto (Objective)
'Cellular regulation by soluble inositol phosphate messengers has yielded surprising knowledge that reaches well beyond the rigorously characterized regulation of Ca2 release by inositol 1,4,5-trisphosphate (IP3), the best-known inositol phosphate. Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that have a range of signaling functions. The best-characterized inositol pyrophosphates are diphosphoinositol pentakisphosphate (IP7) and the bis-diphosphoinositol tetrakisphosphate (IP8). The activity of inositol pyrophosphates appears to be related to their rapid turnover in cells and also to their pyrophosphate groups, considered to contain high-energy bonds and unique signaling molecules implicated in regulation of processes, including apoptosis, telomere maintenance or vesicular trafficking. Inositol phosphate signaling molecules can directly mediate protein phosphorylation, a new way in which signals can be transduced in cells. Another phosphate molecule, inorganic polyphosphate (poly P), found in every living-cell, is a chain of many tens or hundreds of phosphate residues linked by the same phosphoanhydride bonds as in ATP. Poly P likely was a phosphorylating agent and catalyst of peptide bond formation in prebiotic times. It has been shown that poly P is essential in stringent response, survival for bacterial responses to stresses, starvation and pathogenesis. Yeast mutants, affected in enzymes of the inositol pyrophosphate synthesis have reduced intracellular poly P levels suggesting that inositol pyrophosphates are necessary for poly P synthesis and maintenance. The mechanism by which inositol pyrophosphates are able to transduce the cellular phosphate status into a cascade of signaling events is unknown. The present proposal tries to find links between inositol polyphosphate and poly P in relation to poly P synthesis and their role in cell signaling.'