OVOC

Ultra Fast Magnetic Resonance Imaging using One-Voxel-One-Coil Acquisition

 Coordinatore UNIVERSITAETSKLINIKUM FREIBURG 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 2˙495˙600 €
 EC contributo 2˙495˙600 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2008-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-09-01   -   2015-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

 Organization address address: FAHNENBERGPLATZ
city: FREIBURG
postcode: 79085

contact info
Nome: Simone
Cognome: Schwer
Email: send email
Telefono: +49 (0) 761 203 - 4349
Fax: +49 (0) 761 203 - 8842

DE (FREIBURG) beneficiary 196˙800.00
2    UNIVERSITAETSKLINIKUM FREIBURG

 Organization address address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106

contact info
Titolo: Mr.
Nome: Gerhard
Cognome: Henninger
Email: send email
Telefono: +49 761 270 1920
Fax: +49 761 270 1889

DE (FREIBURG) hostInstitution 2˙298˙800.00
3    UNIVERSITAETSKLINIKUM FREIBURG

 Organization address address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106

contact info
Titolo: Prof.
Nome: Jürgen
Cognome: Hennig
Email: send email
Telefono: 497613000000
Fax: 497613000000

DE (FREIBURG) hostInstitution 2˙298˙800.00

Mappa


 Word cloud

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oncology    arrays    cortical    performed    gt    mri    vascular    physiological    primary    investigation    visual    mreg    experiments    ovoc    spatiotemporal    events    fast    quantitative    acquisition   

 Obiettivo del progetto (Objective)

'The proposal is aimed at the development of ultrafast Magnetic Resonance Imaging (MRI) for applications in neuroscience, neurology and oncology. The methodology used is based on the principle of one-voxel-one-coil acquisition in which the sensitive volumes of arrays containing a large number of small receiver coils is used as primary source of spatial localization. This allows to achieve acquisition speed >> 10 fps and opens up new windows of application for MRI. Within this proposal research will be aimed at two areas of application: For investigation of fast physiological events in the brain, applications based on the observation of fast spatiotemporal events by MR-encephalography (MREG) will be developed. MREG will be used for detailed quantitative measurement of differential cortical response during activation of cortical networks by complex stimuli. Primary areas of interest will be the investigation of spatiotemporal response in visual perception, visual and auditory cued tasks and during language processing. In addition to quantitative mapping of response, map functional connectivity with and without correlation with ECG will be investigated. For neurological applications we will use the very high sensitivity of MREG to detect arterial pulsatility in order to generate quantitative, three-dimensional maps of hemodynamic function. Clinical applications for examination of patients with stroke, ischemia, vascular disease and vascular pathologies will be developed. The principles of OVOC-measurements will also be applied in oncology for measurements of fast intrinsic and stimulated physiological events like dynamic measurements of blood flow, tissue permeability and oxygenation in tumors and metastasis. Spectroscopic OVOC-measurements will be developed to observe metabolic turnover. All experiments will be performed both in humans and animal models. Highly localized experiments will be performed using microcoil arrays currently under development.'

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