BIOENGINEERED NICHES

Bioengineering the neural stem cell niche to identify regulators of fate determination

Coordinatore	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE    more  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Matthias Cognome: Lutolf Email: send email Telefono: +41 (0)21 693 18 76 Fax: +41 (0)21 693 96 65
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	190˙297 €
EC contributo	190˙297 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-09-01   -   2012-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Matthias Cognome: Lutolf Email: send email Telefono: +41 (0)21 693 18 76 Fax: +41 (0)21 693 96 65	CH (LAUSANNE)	coordinator	190˙297.28

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 Obiettivo del progetto (Objective)

'Although neural stem cells (NSC) have been isolated successfully and characterized relatively extensively, little is known about the role of their natural microenvironment, the so-called niche, in influencing their behavior. The role of distinct niche signals and their spatial orientation in regulating the choice between quiescence, self-renewal or differentiation is poorly understood, due in part to a lack of suitable in vitro model systems. The main goal of the proposed project is to investigate how extracellular signals affect symmetric/asymmetric cell division of single neural stem cells. This will be achieved by generating artificial microenvironments recapitulating key biochemical and structural characteristics of stem cell niches, that allow to expose NSCs to a variety of protein signals in a spatially-controlled fashion, and allow high-throughput tracking of single stem cells by time-lapse microscopy and retrospective fate analysis. Understanding the basic mechanisms that regulate the balance between self-renewal and differentiation of tissue-resident stem cells will open up new opportunities for their clinical application.'