NANOANTENNA

Development of a high sensitive and specific nanobiosensor based on surface enhanced vibrational spectroscopy dedicated to the in vitro proteins detection and disease diagnosis

Coordinatore	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE    more  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Mr. Nome: Gilles Cognome: Traimond Email: send email Telefono: +33 1 45075017 Fax: +33 1 45075819
Nazionalità Coordinatore	France [FR]
Totale costo	5˙920˙214 €
EC contributo	3˙999˙925 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2009-single-stage
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-10-01   -   2013-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Mr. Nome: Gilles Cognome: Traimond Email: send email Telefono: +33 1 45075017 Fax: +33 1 45075819	FR (PARIS)	coordinator	599˙491.00
2	TECHNOCLONE HERSTELLUNG DIAGNOSTIKAUND ARZNEIMITTELN GMBH  Organization address address: BRUNNERSTRASSE 59/5 city: WIEN postcode: 1230 contact info Titolo: Mrs. Nome: Veronika Cognome: Binder Email: send email Telefono: +43 1 863730	AT (WIEN)	participant	399˙959.00
3	HORIBA JOBIN YVON S.A.S.  Organization address address: Rue du Canal 16-18 city: LONGJUMEAU postcode: 91160 contact info Titolo: Ms. Nome: Blandine Cognome: Mariot Email: send email Telefono: +33 1 64 54 13 90 Fax: +33 1 64 54 13 67	FR (LONGJUMEAU)	participant	367˙092.00
4	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA  Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 contact info Titolo: Mr. Nome: Gabriele Cognome: Ballero Email: send email Telefono: +39 01071781445 Fax: +39 010720321	IT (GENOVA)	participant	340˙131.00
5	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG  Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 contact info Titolo: Dr. Nome: Verena Cognome: Schultz-Coulon Email: send email Telefono: +49 6221 542424 Fax: +49 6221 543599	DE (HEIDELBERG)	participant	319˙946.00
6	BEN-GURION UNIVERSITY OF THE NEGEV  Organization address address: Office of the President - Main Campus city: BEER SHEVA postcode: 84105 contact info Titolo: Ms. Nome: Daphna Cognome: Tripto Email: send email Telefono: +972 8 6472425 Fax: +972 8 6472930	IL (BEER SHEVA)	participant	319˙897.00
7	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Ms. Nome: Giovanna Cognome: Toscano Email: send email Telefono: +39 090 39762 201 Fax: +39 090 3974 130	IT (ROMA)	participant	282˙165.00
8	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Carlos M. Cognome: Abad Ruiz Email: send email Telefono: +3491566 8852 Fax: +34 915668913	ES (MADRID)	participant	279˙891.50
9	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Dr. Nome: Nathalie Cognome: Charnaux Email: send email Telefono: +33 1 48 38 73 53 Fax: +33 1 48 38 77 77	FR (PARIS)	participant	277˙718.30
10	UNIVERSITE DE TECHNOLOGIE DE TROYES  Organization address address: rue Marie Curie 12 city: TROYES postcode: 10010 contact info Titolo: Prof. Nome: Dominique Cognome: Barchiesi Email: send email Telefono: +33 3 25 715 826 Fax: +33 3 25 715 649	FR (TROYES)	participant	273˙950.00
11	Asociacion - Centro de Investigacion Cooperativa en Nanociencias - CIC NANOGUNE  Organization address address: Tolosa Hiribidea 76 city: San Sebastian postcode: 20018 contact info Titolo: Mr. Nome: Miguel Cognome: Odriozola Braconier Email: send email Telefono: +34 943574000 Fax: +34 943574001	ES (San Sebastian)	participant	270˙036.00
12	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES  Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182 city: SAN SEBASTIAN postcode: 20009 contact info Titolo: Dr. Nome: Valery Cognome: Pavlov Email: send email Telefono: +34 943005300 Fax: +34 943005301	ES (SAN SEBASTIAN)	participant	269˙649.00

Mappa

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 Obiettivo del progetto (Objective)

'The main goal of our proposal is to develop a novel optical nanobiosensor based on extraordinary vibrational signal enhancement of the proteins to be detected. To reach vibrational signal enhancement, we will exploit the optical properties of specially designed metallic nanoparticles which should act as nanoantenna and the associated field enhancement to obtain a direct detection of proteins bound to the nanoparticle. Thus, our sensor will reach high sensitivity provided by the recently established large enhancement of vibration signals due to the resonant excitation of the nanoantenna device used as substrates. The aim is to detect only a few proteins with concentration much lower than 1pM and finally to reach detection threshold such as femtomole or lower. High molecular selectivity will be reached with the functionalisation of the nanoantenna. Such functionalisation will selectively favour the immobilisation of the protein to be detected at the vicinity of the nanoparticle surface, providing the best enhancement and then the detection of the targeted protein. Our nanobiosensor will include two main components: the nanoantenna device which corresponds to our sensor transducer and the functionalisation which corresponds to its bioreceptor. And then, each functionalised nanoantenna device used as vibrational signal enhanced system is an individual and specific nanosensor of proteins. As a consequence, our nanobiosensor integrated in a vibrational spectroscope will allow the detection and the analysis of the enhanced vibrational signal from the targeted proteins and thus corresponds to our diagnosis instrument. Our nanobiosensor will be validated on the detection of proteins on body fluids.These proteins have been chosen since they have been identified as specific biomarkers of common pathologies. This validation will be applied it to improve their detection (better sensitivity, decrease of the detection threshold) and open the way to the early diagnosis.'

Introduzione (Teaser)

EU-funded scientists have developed highly sensitive and specific detectors of disease-associated proteins. Technology paves the way to simple blood tests that identify the onset of important diseases for more effective treatment.