CALYX MMFF

Molecular mechanisms of the formation and early function of calyx of Held synapses in the auditory brainstem

Coordinatore	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE    more  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Ralf Cognome: Schneggenburger Email: send email Telefono: +41 21 693 53 64 Fax: +41 21 693 18 97
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	189˙730 €
EC contributo	189˙730 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2011-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Ralf Cognome: Schneggenburger Email: send email Telefono: +41 21 693 53 64 Fax: +41 21 693 18 97	CH (LAUSANNE)	coordinator	189˙730.27

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 Obiettivo del progetto (Objective)

'My long-term goal for an independent research career is to carry forward the understanding of the central auditory system physiology and the molecular mechanisms that underlie its plasticity. Defects in this system may cause several diseases such as auditory neuropathies, tinnitus or impairments in language understanding. For this long-term purpose, I will do my post-doctoral experience in the laboratory of Pr. Schneggenburger (Brain Mind Institute/Ecole Polytechnique Fédérale de Lausanne/Switzerland) who is a world specialist in the study of the calyx of Held, a model synapse that belongs to the brainstem auditory pathway. The overall objective of this proposal is to gain insight into the molecular cues that determine the formation of the large calyces of Held synapses in the auditory brainstem. Calyces of Held are large excitatory glutamatergic synapses of the superior olivary complex, which rapidly relay information on sounds arriving at the contralateral ear. They thus play a role in sound source localization. Despite their important function, the molecular mechanisms which guarantee the correct formation of these synapses during development are unknown. In this project, we will therefore seek to answer the following two questions: 1) What are the molecular mechanisms that guarantee the formation of large calyces of Held synapses on the contralateral side of the brain, 2) What is the role of the Wnt signaling pathway in axon remodeling that ultimately leads to the formation of the large calyx of Held synapse.'