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NAIMIT

Novel immunotherapies for type 1 diabetes

Coordinatore	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Myriam Cognome: Witvrouw Email: send email Telefono: +32 16 320623 Fax: +32 16 326515
Nazionalità Coordinatore	Belgium [BE]
Sito del progetto	http://www.naimit.eu
Totale costo	14˙247˙400 €
EC contributo	10˙920˙800 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2009-single-stage
Funding Scheme	CP-IP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-11-01 - 2015-04-30

Partecipanti

#	participant	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Myriam Cognome: Witvrouw Email: send email Telefono: +32 16 320623 Fax: +32 16 326515	BE (LEUVEN)	coordinator	1˙636˙200.80
2	ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: Albinusdreef 2 city: LEIDEN postcode: 2333 ZA contact info Titolo: Ms. Nome: Sonja Cognome: Croes De Bruin Email: send email Telefono: +31 71 5264765 Fax: +31 71 5265267	NL (LEIDEN)	participant	1˙074˙962.40
3	MEDIZINISCHE HOCHSCHULE HANNOVER Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 contact info Titolo: Ms. Nome: Angela Cognome: Steinhusen Email: send email Telefono: +49 511 5326526 Fax: +49 511 5323584	DE (HANNOVER)	participant	928˙500.00
4	Immunocore Limited Organization address address: Milton Park 57c city: Abingdon postcode: OX14 4RX contact info Titolo: Dr. Nome: Stephen Cognome: Megit Email: send email Telefono: +44 1235 438600 Fax: +44 1235 438601	UK (Abingdon)	participant	832˙500.00
5	KING'S COLLEGE LONDON Organization address address: Strand city: LONDON postcode: WC2R 2LS contact info Titolo: Mr. Nome: Paul Cognome: Labbett Email: send email Telefono: +44 207 8488184 Fax: +44 207 8488187	UK (LONDON)	participant	805˙299.60
6	UNIVERSITY OF BRISTOL Organization address address: TYNDALL AVENUE SENATE HOUSE city: BRISTOL postcode: BS8 1TH contact info Titolo: Mr. Nome: Vince Cognome: Boyle Email: send email Telefono: +44 117 3317575 Fax: +44 117 9250900	UK (BRISTOL)	participant	709˙845.60
7	UNIVERSITE LIBRE DE BRUXELLES Organization address address: Avenue Franklin Roosevelt 50 city: BRUXELLES postcode: 1050 contact info Titolo: Mr. Nome: Patrick Cognome: Goblet Email: send email Telefono: +32 2 6503302 Fax: +32 2 6504575	BE (BRUXELLES)	participant	699˙300.00
8	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Mr. Nome: Keith Cognome: Cann Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	participant	670˙500.00
9	ActoGeniX NV Organization address address: Technologiepark 4 city: Zwijnaarde postcode: 9052 contact info Titolo: Ms. Nome: Magda Cognome: Van Hijfte Email: send email Telefono: +32 9 2610675 Fax: +32 9 2610619	BE (Zwijnaarde)	participant	652˙500.00
10	JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN Organization address address: GRUNEBURGPLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 contact info Titolo: Mr. Nome: Rolf Cognome: Draeger Email: send email Telefono: +49 69 6301 6854 Fax: +49 69 6301 81087	DE (FRANKFURT AM MAIN)	participant	650˙100.00
11	FUNDACAO CALOUSTE GULBENKIAN Organization address address: AVENIDA DE BERNA 45A city: LISBOA postcode: 1000 contact info Titolo: Mr. Nome: Jose Mario Cognome: Leite Email: send email Telefono: +351 214407937 Fax: +351 214407970	PT (LISBOA)	participant	597˙300.00
12	UNIVERSITA' DEGLI STUDI DI SIENA Organization address address: VIA BANCHI DI SOTTO 55 city: SIENA postcode: 53100 contact info Titolo: Prof. Nome: Silvano Cognome: Focardi Email: send email Telefono: +39 0577232206 Fax: +39 0577232202	IT (SIENA)	participant	596˙100.00
13	CARDIFF UNIVERSITY Organization address address: Newport Road 30-36 city: CARDIFF postcode: CF24 ODE contact info Titolo: Mr. Nome: Nick Cognome: Bodycombe Email: send email Telefono: +44 29 20877135 Fax: +44 29 2087 4189	UK (CARDIFF)	participant	511˙154.40
14	UNIVERSITA DI PISA Organization address address: Lungarno Pacinotti 43/44 city: PISA postcode: 56126 contact info Titolo: Prof. Nome: Enio Cognome: Martino Email: send email Telefono: +39 050 995010 Fax: +39 050 995086	IT (PISA)	participant	494˙100.00
15	DanDrit Biotech A/S Organization address address: Fruebjergvej 3 city: Copenhagen postcode: 2100 contact info Titolo: Dr. Nome: Mai-Britt Cognome: Zocca Email: send email Telefono: +45 3917 9845 Fax: +45 3917 9900	DK (Copenhagen)	participant	62˙437.20

Mappa

Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

destruction cells interventions clinical steroid beta wp restoration cell t protection disease tolerance mucosal immune antigen

Obiettivo del progetto (Objective)

'This proposal will pioneer the concept of tailored interventions with minimal immune system interference in new onset T1DM, leading to beta-cell protection and restoration, based on a solid understanding of the disease pathogenesis. This will enable experimental findings to be adopted for future clinical application. Four work packages are grouped around ‘Reversal of autoimmunity’, in which two key players of the immune system in beta-cell destruction will be targeted: the dendritic cell (WP1: Re-educating antigen-presenting cells) and the T-lymphocyte (WP2: Restoring the T-cell balance). In both cell types, interventions using steroid hormones (vitamin D and glucocorticoids) will be used to induce tolerance. Moreover, novel interventions using soluble T-cell receptors to target immune cells and beta-cells in an antigen-specific way (WP3: TCR-mediated immunotherapy) will be introduced. Novel mucosal interventions using probiotics and recombinant L. lactis as a carrier for specific peptides in combination with cytokines (WP4: Mucosal intervention for tolerance restoration) will be studied for their immune modulating potential. A full work package (WP5: Beta-cell protection and restoration – the dialogue with the immune system) is dedicated to the beta-cell and its role in driving and amplifying the immune attack through communication between beta-cells and the immune system. The last scientific work package (WP6: Pharmacogenetics) will identify genetic profiles within patients that predict responsiveness to the steroid interventions proposed. WP7 and 8 are dedicated to training and management of the consortium. For this purpose, a multidisciplinary consortium of leading European diabetologists and immunologists from 11 academic research institutions, in co-operation with 3 SMEs developing novel technologies allowing translation of basic research results towards clinical applications, has been established.'

Introduzione (Teaser)

Type 1 diabetes (T1D) is an autoimmune disease, in which the insulin-producing beta cells are destroyed by infiltrating immune cells. Recent evidence has made it clear that the beta cells, next to the destructive role of the immune system, are also playing an active role in their own destruction.