BIOACTIVECPDS

Biologically Active Organic Compounds Interacting with Adenine-binding Proteins

Coordinatore	Masarykova univerzita    more  Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 contact info Titolo: Dr. Nome: Ctibor Cognome: Mazal Email: send email Telefono: +420 54949 1429 Fax: +420 54949 2688
Nazionalità Coordinatore	Czech Republic [CZ]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IRG-2008
Funding Scheme	MC-IRG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2015-05-01

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Masarykova univerzita  Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 contact info Titolo: Dr. Nome: Ctibor Cognome: Mazal Email: send email Telefono: +420 54949 1429 Fax: +420 54949 2688	CZ (BRNO STRED)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases. The structures contain heterocyclic cores relatively unknown in the literature and will mimic interations of purine-containing biological substrates (especially ATP) with proteins that are relevant in oncology. The compounds will be synthesized by modern methods of organic synthesis, namely by ring-closing olefin metathesis and will be profiled in biological assays that include diverse biological targets, especially those that are related to the treatment of cancer.'