ROLE OF SPIS

The role of Salmonella Pathogenicity Islands in salmonellosis outbreaks and invasive disease

Coordinatore	MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER    more  Organization address address: TEL HASHOMER SHEBA MEDICAL CENTER city: RAMAT GAN postcode: 52621 contact info Titolo: Mr. Nome: Moshe Cognome: Barak Email: send email Telefono: 972-3-530-3578 Fax: 972-3-530-5717
Nazionalità Coordinatore	Israel [IL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-RG
Funding Scheme	MC-IRG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-02-01   -   2014-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER  Organization address address: TEL HASHOMER SHEBA MEDICAL CENTER city: RAMAT GAN postcode: 52621 contact info Titolo: Mr. Nome: Moshe Cognome: Barak Email: send email Telefono: 972-3-530-3578 Fax: 972-3-530-5717	IL (RAMAT GAN)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Non-typhoid Salmonella (NTS) enterica is a major cause of foodborne infections in industrialized countries and a leading cause of hospitalization and death among bacterial foodborne pathogens. The vast majority of the Salmonella virulence factors are encoded within horizontally acquired discrete regions along the chromosome known as Salmonella Pathogenicity Islands (SPIs). SPIs are crucial for Salmonella virulence. Herein we propose to study the role of 17 SPIs and associated virulence loci in different aspects of NTS pathogenicity including the ability to cause outbreaks, host-to-host transmission, and manifestation of invasive disease. In the first stage of the study we will map and characterize the distribution of these virulence loci across various outbreak and bacteremia isolates. This analysis will provide a broad view over the distribution of SPIs in highly virulence isolates, which are clinically relevant in Israel and Europe. Based the collected data, we will develop a Quantitative Microbial Risk Assessment approach for detection of virulent Salmonella strains in food, environmental and livestock samples. In addition we are interested in investigating the potential contribution of SPIs to the oral-fecal route of transmission. To do so, we will use the persistent mouse model and study the ability of Salmonella strains, harboring SPIs deletions to transmit the disease over time. The gained data are expected to yield a broader understanding about the role of primary virulence loci in the pathogenesis and epidemiology of Salmonella and will shed light on the evolution of pathogenic Salmonella serotypes. Understanding these mechanisms will contribute to our knowledge about host-pathogen interactions and the molecular basis of outbreaks. Deeper understanding about these processes could lead to better prevention and treatment of infectious diseases and may provide new therapeutic targets for the development of novel antimicrobial chemotherapies and vaccines.'

Introduzione (Teaser)

Salmonella enterica is a major threat to human health and is a highly versatile pathogen that can infect many animals including humans. European research is finding out the key to its ability to cause diseases.