CLEAR

Modulating cellular clearance to cure human disease

 Coordinatore FONDAZIONE TELETHON 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Italy [IT]
 Totale costo 2˙100˙000 €
 EC contributo 2˙100˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-03-01   -   2015-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FONDAZIONE TELETHON

 Organization address address: VIA VARESE 16/B
city: ROMA
postcode: 185

contact info
Titolo: Ms.
Nome: Irene
Cognome: Mearelli
Email: send email
Telefono: +39 0644 0151
Fax: +39 0644 015521

IT (ROMA) hostInstitution 2˙100˙000.00
2    FONDAZIONE TELETHON

 Organization address address: VIA VARESE 16/B
city: ROMA
postcode: 185

contact info
Titolo: Prof.
Nome: Andrea
Cognome: Ballabio
Email: send email
Telefono: +39 081 6132212
Fax: +39 081 5790919

IT (ROMA) hostInstitution 2˙100˙000.00

Mappa


 Word cloud

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genomics    disease    goals    lysosomal    modulate    diseases    cellular    clearance    biology    neurodegenerative    physiological    neurodegeneration    network    therapies    clear    function    human    mechanisms    tools   

 Obiettivo del progetto (Objective)

'Cellular clearance is a fundamental process required by all cells in all species. Important physiological processes, such as aging, and pathological mechanisms, such as neurodegeneration, are strictly dependent on cellular clearance. In eukaryotes, most of the cellular clearing processes occur in a specialized organelle, the lysosome. This project is based on a recent discovery, made in our laboratory, of a gene network, which we have named CLEAR, that controls lysosomal biogenesis and function and regulates cellular clearance. The specific goals of the project are: 1) the comprehensive characterization of the mechanisms underlying the CLEAR network, 2) the thorough understanding of CLEAR physiological function at the cellular and organism levels, 3) the development of strategies and tools to modulate cellular clearance, and 4) the implementation of proof-of-principle therapeutic studies based on the activation of the CLEAR network in murine models of human lysosomal storage disorders and of neurodegenerative diseases, such as Alzheimers s and Huntington s diseases. A combination of genomics, bioinformatics, systems biology, chemical genomics, cell biology, and mouse genetics approaches will be used to achieve these goals. Our goal is to develop tools to modulate cellular clearance and to use such tools to develop therapies to cure human disease. The potential medical relevance of this project is very high, particularly in the field of neurodegenerative disease. Therapies that prevent, ameliorate or delay neurodegeneration in these diseases would have a huge impact on human health.'

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Neural basis of Drosophila mating behaviours

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SM-DNA-REPAIR (2008)

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DBF (2009)

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