PORPH_IMP_SHG

Porphyrin-Based Dyes for Imaging Membrane Potential via Second Harmonic Generation

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD    more  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	172˙740 €
EC contributo	172˙740 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-05-01   -   2012-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	coordinator	172˙740.80

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Based on recently published work from Anderson’s group in Oxford, this proposal aims to develop a new technique for optical imaging of membrane potential in living cells using second-harmonic generation (SHG) microscopy with porphyrin-based dyes. This technology should enable the function of neurons, and other excitable cells, to be monitored in real time, with high spatial resolution, in their native networks. The objectives of this project include (1) the synthesis of new porphyrins that bind efficiently to the plasma membranes of cells, exhibit strong voltage-dependent SHG and which avoid photo-damage and phototoxicity, and (2) the demonstration that these dyes can be used to monitor membrane potential in living cells. Prof. Anderson's group in Oxford has pioneered research into porphyrin-based nonlinear optical dyes for many years, and has great expertise in this area. The Department of Chemistry in Oxford has world-class facilities for this research. Ismael López Duarte will soon complete his PhD in the field of phthalocyanine chemistry, but he has no experience in the synthesis of porphyrins, nor of the design and testing of dyes for biological applications. This Fellowship will give him the opportunity to apply his expertise in synthesis to the creation of useful new biological probes. It will provide him with experience in a new and rapidly growing area of research and enable him to broaden his horizons.'