AIDS AND MIRNAS
Application of massive parallel sequencing to microRNA profiling of cellular and molecular response to HIV-1 and HIV-2 infection and to modulation of integration
| Coordinatore | FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA
Organization address
address: CAMPO GRANDE EDIFICIO C1 PISO 3 contact info |
| Nazionalità Coordinatore | Portugal [PT] |
| Totale costo | 45˙000 € |
| EC contributo | 45˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2009-RG |
| Funding Scheme | MC-ERG |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-07-01 - 2013-11-29 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA
Organization address
address: CAMPO GRANDE EDIFICIO C1 PISO 3 contact info |
PT (LISBOA) | coordinator | 45˙000.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'miRNAs are key regulators of cell function and pathogen infection. The identification of miRNAs involved inHIV infection promises to offer unique insights into disease mechanisms and to help identify novel targets for therapy. However, the ability to perform an unbiased characterization of miRNA expression has only recently become possible through the use of massive parallel sequencing. This proposal aims to generate the first whole-genome map of miRNA expression during HIV-1 and HIV-2 infection in primary lymphocytes using these novel sequencing techniques. Furthermore, we will identify miRNAs associated with key steps of infection by combining sequencing with the use of drug inhibitors that block viral DNA integration. We expect to identify miRNAs required for the progression of viral infection, with potential for future use in anti-HIV therapy. Pathways associated with differential miRNA expression between HIV-1 and HIV-2 will provide insights into the mildness of HIV-2 infection, providing clues for new strategies against HIV-1.'