Positive

A highly integrated and sensitive PORous SIlicon based lab on a chip for multiple quantitaTIVE monitoring of Food allergies at point of care

Coordinatore	UNIVERSITAT DE VALENCIA    more  Organization address address: AVENIDA BLASCO IBANEZ 13 city: VALENCIA postcode: 46010 contact info Titolo: Ms. Nome: Angeles Cognome: Sanchis Email: send email Telefono: +34 96 3983621 Fax: +34 96 3937729
Nazionalità Coordinatore	Spain [ES]
Totale costo	3˙740˙831 €
EC contributo	2˙900˙000 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2009-5
Funding Scheme	CP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-01   -   2014-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAT DE VALENCIA  Organization address address: AVENIDA BLASCO IBANEZ 13 city: VALENCIA postcode: 46010 contact info Titolo: Ms. Nome: Angeles Cognome: Sanchis Email: send email Telefono: +34 96 3983621 Fax: +34 96 3937729	ES (VALENCIA)	coordinator	0.00
2	CHARITE - UNIVERSITAETSMEDIZIN BERLIN  Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 contact info Titolo: Ms. Nome: Eveline Cognome: Fräßdorf Email: send email Telefono: +49 30 450 57 60 24 Fax: +49 30 450 57 69 54	DE (BERLIN)	participant	0.00
3	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: PIAZZALE ALDO MORO city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Riva Cognome: Sergio Email: send email Telefono: +39 02 2850 0035 Fax: +39 02 2890 1239	IT (ROMA)	participant	0.00
4	CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT  Organization address address: RUE JAQUET DROZ city: NEUCHATEL postcode: 2002 contact info Titolo: Dr. Nome: Helmut Cognome: Knapp Email: send email Telefono: +41 41 672 75 23 Fax: +41 41 672 75 00	CH (NEUCHATEL)	participant	0.00
5	Farfield Group Limited  Organization address address: CHICAGO AVENUE WEST WING LEVEL city: MANCHESTER postcode: M90 3DQ contact info Titolo: Ms. Nome: Louise Cognome: Madden Email: send email Telefono: +44 161 436 9700	UK (MANCHESTER)	participant	0.00
6	KUNGLIGA TEKNISKA HOEGSKOLAN  Organization address address: Valhallavaegen city: STOCKHOLM postcode: 10044 contact info Titolo: Ms. Nome: Erika Cognome: Appel Email: send email Telefono: +46 8 790 7786 Fax: +46 8 100858	SE (STOCKHOLM)	participant	0.00
7	PHYLOGENE  Organization address address: 62RTE Nationale city: Bernis postcode: 30620 contact info Titolo: Mr. Nome: gilbert Cognome: Skorski Email: send email Telefono: +33 4 66 04 77 99 Fax: +33 4 66 04 77 97	FR (Bernis)	participant	0.00
8	UNIVERSITA DEGLI STUDI DI TRENTO  Organization address address: VIA BELENZANI city: TRENTO postcode: 38122 contact info Titolo: Prof. Nome: Lorenzo Cognome: Pavesi Email: send email Telefono: 390462000000 Fax: 390462000000	IT (TRENTO)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

By integrating and interfacing multiple core technologies and related materials from fluidics and photonics technology to porous silicon (porSi) and polymers, Positive will target the implementation of a microsystem tailored to a specific application with a key societal and economic need. The very high surface to volume ratio of porSi permits very high surface densities of bound antibody-antigen complexes in a reduced volume that through a novel optical interaction leads to scores of sensing areas on a 1cm2 chip with detection-limits down to ~0.1 pg/mm2, significantly beyond state of the art for highly integrated label free sensors at point of care. This offers the further advantageous possibility of assaying several parameters simultaneously (multi-assay) leading to further increases in the reliability and reductions in the measurement uncertainty of a diagnostic over single-parameter assays. The novel Lab-on-Chip technology has the potential to be fast and easy to use, making routine screening or monitoring with immunoassays more cost-effective.The ultimate goal of Positive will be to demonstrate a safe and rapid low cost diagnostic test for food allergies at point of care such as in a GP's office or hospital. A quantitative determination of allergy sensitization is expected within ~15' of adding no more than 100µl of blood. A final prototype consisting of a packaged biochip and reader will be used on clinical samples in order to determine sensitization to allergens such as that for hen's eggs, cow's milk, peanuts, wheat, treenuts, fish, sesame, and shrimp ingestion.The two industrial partners with their international market strategies and a clinical specialist for food allergies in children as an end-user will enable us to target the whole value chain from research to validation. It is therefore expected that this novel and beyond state of the art Lab-on -Chip will give impetus to the global competitiveness and profitability of European industry in Microsystems activities.

During the course of the project, after several different lengthy and comprehensive exploratory activities, it was realised that the development of a suitable porous silicon membrane for a marketable Positive biosensor platform, if possible could not be done within the lifetime of the project. In parallel, porous alumina was found to have both optimal fluidic and similar optical properties as well as being commericially available at a low cost and with less or no problems for freedom to operate as part of a final commericial Positive platform. For that reason, some porSi related objectives, milestones, deliverables and tasks have been cancelled.