Coordinatore | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
Nazionalità Coordinatore | France [FR] |
Totale costo | 100˙000 € |
EC contributo | 100˙000 € |
Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
Code Call | FP7-PEOPLE-2009-RG |
Funding Scheme | MC-IRG |
Anno di inizio | 0 |
Periodo (anno-mese-giorno) | 0000-00-00 - 0000-00-00 |
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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | coordinator | 100˙000.00 |
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
'Hair cells of the vertebrate cochlea have the remarkable property to transduce mechanical sound waves into electrical signals at the auditory nerve fibers. This sensory activity involves tightly regulated intracellular Ca2 microdomains, both at the apical stereocilia level (Ca2 influx through the mechano-sensitive channels) and the basolateral synaptic ribbon active zones (Ca2 influx through L-type Ca2 channels). Intense hair cell activity, that is spontaneous during development or evoked by sound stimulation in mature hair cells, should produce transient focal extracellular Ca2changes ([Ca2] ext) in the endolymph and synaptic clefts. The question of [Ca2] ext signaling, while importantly addressed in central neurons, has never been investigated in auditory hair cells. Our preliminary results reveal for the first time a strong expression of the calcium sensing receptor (CaSR) in hair cells. CaSR is a G-protein-coupled membrane protein (GPCR) that detects small fluctuations in [Ca2] ext. The goal of this application is to characterize the role of CaSR in mature and developing hair cell. We will develop a method for CaSR gene silencing using in-ovo electroporation in chick embryos. We will subsequently characterize any morphological and functional changes within the inner ear. Our proposed project could provide a novel view of Ca2 homeostasis in the inner ear. This would increase our understanding of the function of Ca2 signaling in the development of auditory system and maturation of hair cells. Interestingly, in humans, mutations in the gene coding for CaSR produce deafness. Thus, this study may also contribute to the treatment of hearing disorders whose pathology lies within the developing hair cells. This project and funding will serve as part of my training towards my goal of establishing my independent research in auditory physiology.'
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