ADCC

Understanding and manipulating Antibody Dependent Cell Cytotoxicity (ADCC) by human Natural Killer (NK) cells

Coordinatore	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE    more  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Brooke Cognome: Alasya Email: send email Telefono: +44 207 594 1181 Fax: +44 207 594 1418
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	37˙500 €
EC contributo	37˙500 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-ERG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-01   -   2013-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Brooke Cognome: Alasya Email: send email Telefono: +44 207 594 1181 Fax: +44 207 594 1418	UK (LONDON)	coordinator	37˙500.00

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 Obiettivo del progetto (Objective)

'High-resolution microscope images of immune cells contacting other cells have revealed temporary membrane structures, often called immune synapses (IS). Proteins commonly segregate into specific regions at the contacts between cells, and exploring how such changing arrangements of proteins occur and how they control immune cell communication is the new science opened up by the immune synapse concept. Over the last decade the use of monoclonal antibodies has revolutionised the treatment of severe human diseases, such as non hodgkins lymphoma (NHL) and rheumatoid arthritis (RA). One way that these antibodies work is by triggering Natural Killer cells to directly kill diseased target cells. Typically antibodies have been used to either block ligand receptor interactions or to evoke antibody effector function and kill malignant target cells by antibody-dependent cell cytotoxicity (ADCC). Crucially, nobody has yet determined what happens at IS when antibodies trigger killing of diseased cells. Through this project we will focus our research to improve our basic understanding of the molecular dynamics that occur during ADCC and to investigate antibodies specifically engineered to enhance ADCC. Here, we plan to use state-of-the-art technologies to image IS during antibody-mediated killing with a view to learning how to best optimize antibodies for this function. Specifically, the spatial relationship and segregation of proteins at the submicrometer scale will be determined during ADCC and compared for the different antibodies and model systems developed. This will establish what determines the efficiency of ADCC and will facilitate the rational design of modified antibodies for optimal medical use. This project will benefit from the knowledge and experience in imaging and cell biology techniques gained by the researcher during her initial training. It will also provide the researcher with invaluable new experience adding to her career development.'