ANTI-APOPTOTIC NLEH
"Investigating the anti-apoptotic properties of NleH, an effector of the diarrheagenic pathogens Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC)."
| Coordinatore | IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 182˙103 € |
| EC contributo | 182˙103 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2009-IIF |
| Funding Scheme | MC-IIF |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-04-01 - 2012-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | coordinator | 182˙103.20 |
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Obiettivo del progetto (Objective)
'Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic Escherichia coli (EHEC) are closely related diarrheagenic pathogens that are important causes of morbidity and mortality worldwide, especially in young children. EPEC and EHEC are known as attaching and effacing pathogens because they intimately adhere to gut enterocytes and instigate effacement of brush border microvilli. Injection of bacterial effector proteins via a type III secretion system (T3SS) is an integral part of the EPEC and EHEC infection strategy. One such effector, EspF, binds and induces degradation of the anti-apoptotic protein AbcF2, however, although infected cells show early apoptotic symptoms, they do not present late apoptosis signs. The T3SS effectors NleH1 and NleH2 were recently found to have a broad range anti-apoptotic activity which may neutralise the effect of EspF and promote cell survival. In this proposal we wish to investigate the anti-apoptotic activity of NleH, in particular its binding to the endoplasmic reticulum (ER) anti-apoptotic protein Bax inhibitor-1 (BI-1) and to PDZ domain-containing protein/s.'