MICROCARE

Microsystems and Bioanalysis Platforms for Health Care MICROCARE

 Partecipanti

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Microsystems and Bioanalysis Platforms for Health Care - MICROCARE Miniaturisation of analytical systems is generally considered to be the strategy that will overcome the requirements of process speed for performing efficient evaluation studies. By utilising the versatility of silicon micromachining to fabricate efficient minute volume microstructures, it is possible to make analysis systems that are extremely small. The benefits of miniaturisation stem from the increased reaction kinetics in low volumes and the possibility to perform sample-handling procedures at a high speeds. Our research proposal is focussed on the implementation of micro/nano fabrication technologies for functionalised systems and sensors for bio-chemical analysis and micro delivery based on microtransducer array and micromachined modules. We propose to develop microfluidic devices, surface structuring and chemical organization methods to study both synthetic and systems biology. Additionally MEMS based devices will be developed for applications in life science research. The purpose is to form a network with the following aims: 1) to exploit synergies and complementarities (expertise and facilities) within the multidisciplinary partnership, through researcher mobilization, to conduct a focused research in life science 2) to address some of the theoretical and technological challenges, e.g. static and kinetic analyses with single molecular and cellular resolution and high throughput capabilities, 3) to use micro and nano techniques to develop appropriate systems and platforms to facilitate the defined research 4) develop a set of MEMs based devices for biomedical applications and 5) create a research climate within the partnership for long term collaboration between EU and China in this particular field. Investigations will be conducted through a collaborative process facilitated by a balanced exchange of researchers within the consortium.'

Introduzione (Teaser)

Chinese and European researchers joined forces to develop novel miniature devices for the biomedical field. Exploiting nano-patterning and microfluidics, the plethora of systems and applications promises to revolutionise analytics and delivery of minute amounts of fluids.

Descrizione progetto (Article)

Miniaturisation of bioanalytical platforms can significantly enhance processing speeds due to fast handling and reaction kinetics of minute sample volumes. This eventually is a promising step towards single-molecule or single-cell resolution.

A fruitful collaboration between Chinese and European research institutes fostered extensive development in the fields of microelectromechanical systems and microfluidic devices for biomedical applications. EU funding of the project 'Microsystems and bioanalysis platforms for health care MICROCARE' (MICROCARE) supported the effort.

Research focused on exploiting the versatility of silicon micro- and nanofabrication technologies to produce systems and devices for biochemical analysis and micro-delivery. The team combined nano-patterning techniques and advanced polymeric materials such as transparent conductive polymers or piezoelectric compounds.

More specifically, scientists developed surface structuring and chemical organisation methods as well as techniques to produce micro- and nano-structured patterns. The latter were used to study the role of surface patterning on cellular behaviours such as differentiation, growth and alignment. Partners also designed and tested the feasibility of microfluidic channels with integrated micro- and nano-patterned structures, which were generated by nanoimprint lithography.

Among the numerous devices achieved within the four-year MICROCARE project were new scaffolds for tissue engineering and novel microfluidic devices for diagnosis of tumour cells and for the study of synthetic and systems biology. Chemical and biological sensors of oxygen, glucose and lactate will aid not only in diagnosis of diseases but also in understanding chemical signalling in cells. In the future, such platforms may be used to actually control cell signalling and cell regulation. Scientists integrated some devices for 3D imaging or spectroscopy.

The large variety of miniaturised sensor devices and novel techniques developed within the scope of MICROCARE could have important benefits in the health care realm and beyond. Advancement in portable, efficient and reliable diagnostics with lower costs and faster throughput will enhance the European competitive position in a large global market while enhancing quality of life for EU citizens.