3D3CSI

Three-dimensional Clinical Coherent Chemically-sensitive Imaging

Coordinatore	MEDIZINISCHE UNIVERSITAET WIEN    more  Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Wolfgang Cognome: Drexler Email: send email Telefono: +43 1 40400 1986 Fax: +43 1 40400 3988
Nazionalità Coordinatore	Austria [AT]
Totale costo	170˙481 €
EC contributo	170˙481 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-01-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MEDIZINISCHE UNIVERSITAET WIEN  Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Wolfgang Cognome: Drexler Email: send email Telefono: +43 1 40400 1986 Fax: +43 1 40400 3988	AT (WIEN)	coordinator	170˙481.20

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 Obiettivo del progetto (Objective)

'Three-dimensional Clinical Coherent Chemically-sensitive Imaging A multimodal imaging project between the fellow Dr. Unterhuber with expertise in laser physics and optical instrumentation from Cardiff University, and the host, Prof. Drexler from the Center of Medical Physics and Biomedical Engineering, Medical University Vienna, is proposed. The purpose is to synergistically integrate state-of-the-art ultrahigh axial resolution Optical Coherence Tomography (OCT) towards functional imaging and increase Coherent Anti-Stokes Raman Spectroscopy (CARS) sensitivity by exploitation of non-linear optical amplification using heterodyne detection similar to OCT. OCT has been established as a powerful non-invasive, high resolution imaging modality. Several hundredth megavoxel/s can be scanned due to high speed, high sensitivity frequency domain OCT, permitting real time dynamic volumetric imaging of scattering tissue. OCT permits extremely high sensitivity and speed, though it cannot easily distinguish different chemical substances – CARS - is one of the most potential techniques with the ability to extract specific biochemical solely based on endogenous signals. Until now the complexity for integrating both technologies that involve sophisticated laser sources causes a major technical challenge. Novel developments in CARS technology have paved a way to simplify the setup utilizing ultrabroad lasers also found in ultrahigh axial resolution OCT. The aim is to demonstrate the general feasibility of a compact and simple medical instrument capable of collecting morphological and depth resolved functional information at cellular level simultaneously in a clinical environment with the purpose of unprecedented non-invasive detection of metabolic, tissue information. The capabilities of such a device will have the potential to significantly improve the understanding of physiologic and pathologic processes without exogenous labels in their native 3D-environment.'